Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately
one-third of people infected with the protozoan parasite Trypanosoma cruzi. One way T …

Chagas disease caused by Trypanosoma cruzi remains an important neglected tropical
disease and a cause of significant morbidity and mortality. No longer confined to endemic …

Directed leukocyte migration is a hallmark of inflammatory immune responses. Leukotrienes
are derived from arachidonic acid and represent a class of potent lipid mediators of …

Background Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in
Latin America and is widely distributed worldwide because of migration. In 30% of cases …

Aims: The reaction of nitric oxide and nitrite-derived species with polyunsaturated fatty acids
yields electrophilic fatty acid nitroalkene derivatives (NO2-FA), which display anti …

ATP is an important signaling molecule in the immune system, and it is able to bind the
P2X7 purinergic receptor. Recently, our group showed that ATP-treated macrophages …

Infections with the parasitic protozoan Trypanosoma cruzi cause Chagas disease, which
results in serious cardiac and/or digestive pathology in 30%–40% of individuals. However …

Infection with Trypanosoma cruzi induces inflammation, which limits parasite proliferation
but may result in chagasic heart disease. Suppressor of cytokine signaling 2 (SOCS2) is a …

Chagas' disease, produced by Trypanosoma cruzi, affects more than 8 million people,
producing approximately 10,000 deaths each year in Latin America. Migration of people …