Antitumor T lymphocytes play a pivotal role in immunosurveillance of malignancy. The CTL
antigen 4 (CTLA-4) is a vital negative regulator of T-cell activation and proliferation. This …

Earlier published studies investigating the association between polymorphisms in the
angiotensinogen gene and lung cancer risk showed no consistent results. In this study, we …

REV3Lp, the catalytic subunit of DNA polymerase zeta, is the major participant in translesion
DNA synthesis. Recent evidence suggests that REV3L has an important role in the …

Apurinic/apyrimidinic endonuclease 1/redox effector factor‐1 (APE1/Ref‐1) is a ubiquitous
multifunctional protein that possesses both DNA‐repair and redox regulatory activities …

To assess systematically whether potentially functional polymorphisms in DNA repair genes
influence the clinical behavior of non‐small‐cell lung cancer (NSCLC), we examined the …

Rationale: Previously, we reported that common variants in precursor microRNA (pre-
miRNA) sequences played a role in the prediction of non–small cell lung cancer (NSCLC) …

Methods Eight selected single-nucleotide polymorphisms in AHR were genotyped using the
Illumina SNP genotyping BeadLab platform in a case–control study of 500 lung cancer …

One-carbon metabolism facilitates the cross-talk between genetic and epigenetic processes,
making it a good candidate for studying the risk of lung cancer. To investigate the role of …

Exonuclease 1 (EXO1) is an important nucleases involved in mismatch repair system that
contributes to maintain genomic stability, to modulate DNA recombination, and to mediate …

Over the last decades, combined chemotherapies that inhibit different signalling pathways
together have been demonstrated to be more effective to treat the non-small-cell lung cancer …