Anhedonia is one of the core symptoms of major depressive disorder (MDD), which is often
inadequately treated by traditional antidepressants. The modern framework of anhedonia …

Both human and animal studies support the relationship between depression and reward
processing abnormalities, giving rise to the expectation that neural signals of these …

Renewed interest in classic psychedelics as treatments for psychiatric disorders warrants a
deeper understanding of their neural mechanisms. Single, high doses of psychedelic drugs …

Mechanisms and predictors for the successful treatment of anxiety and depression have
been elusive, limiting the effectiveness of existing treatments and curtailing the development …

BackgroundReward dysfunction is a major dimension of depressive symptomatology, but it
remains obscure if that dysfunction varies across different reward types. In this study, we …

Reduced activation of positive valence systems (PVS), including blunted neural and
physiological responses to pleasant stimuli and rewards, has been shown to prospectively …

Anhedonia is a cardinal characteristic of depression which predicts worse treatment
outcome and is among the most common residual symptoms following treatment. Behavioral …

BackgroundAerobic exercise has demonstrated antidepressant efficacy among adults with
major depression. There is a poor understanding of the neural mechanisms associated with …

Performance-monitoring event-related brain potentials (ERPs), such as the error-related
negativity (ERN) and reward positivity (RewP), are advocated as biomarkers of depression …

Background The reward circuit is important for motivation and learning, and dysregulations
of the reward circuit are prominent in anhedonic depression. Noninvasive interventions that …