The fundamental basis of muscle contraction 'the sliding filament model'(;) and the 'swinging,
tilting crossbridge-sliding filament mechanism'(;) nucleated a field of research that has …

It is now firmly established that the contraction of muscle and many of the movements of
nonmuscle cells result from the interaction of two proteins, actin and myosin. These …

Relaxation of vertebrate skeletal muscle is thought to occur in the absence of Ca 2+ as a
result of tropomyosin physically blocking the binding of myosin to actin. This steric blocking …

The mechanics of the actomyosin interaction have been extensively studied using the
organized filament array of striated muscle. However, the extrapolation of these data to the …

In vitro at low ionic strength (mu= 0.02 M) and 5 degrees C, myosin subfragment-1 shows
significant binding to regulated actin in the presence of ATP, independent of the …

The mechanical compliance (reciprocal of stiffness) of thin filaments was estimated from the
relative compliance of single, skinned muscle fibers in rigor at sarcomere lengths between …

A number of recent observations by probe and X-ray methods on the behaviour of
crossbridges during contraction is considered in relation to the energetics of the process. It is …

Electron micrographs showing different cross-bridge orientations in different states of muscle
fibres, and X-ray diffraction patterns indicating axial cross-bridge disorder in contracting …

In the present study, myosin heavy chain (MHC) content per half sarcomere, an estimate of
the number of cross bridges available for force generation, was determined in rat diaphragm …

Low-angle X-ray diffraction diagrams have been recorded from frog sartorius muscles with a
time resolution of a few milliseconds, using synchrotron radiation. The layer-line reflections …