Few human pathogens have been the focus of as much concentrated worldwide attention as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …

The twenty-first century has already recorded more than ten major epidemic or pandemic
virus emergence events, including the ongoing and devastating coronavirus disease 2019 …

Drug discovery campaigns against COVID-19 are beginning to target the SARS-CoV-2 RNA
genome. The highly conserved frameshift stimulation element (FSE), required for balanced …

Approximately 17 years after the severe acute respiratory syndrome coronavirus (SARS-
CoV) epidemic, the world is currently facing the COVID-19 pandemic caused by SARS …

The intrinsic property of cell-penetrating peptides (CPPs) to deliver therapeutic molecules
(nucleic acids, drugs, imaging agents) to cells and tissues in a nontoxic manner has …

The ongoing COVID-19 pandemic, periodic recurrence of viral infections, and the
emergence of challenging variants has created an urgent need of alternative therapeutic …

Genetic decoding is not 'frozen'as was earlier thought, but dynamic. One facet of this is
frameshifting that often results in synthesis of a C-terminal region encoded by a new frame …

Abstract Peptide Nucleic Acids (PNAs) are the DNA/RNA analogues in which sugar-
phosphate backbone is replaced by N-2-aminoethylglycine repeating units. PNA contains …

While ribosomes must maintain translational reading frame in order to translate primary
genetic information into polypeptides, cis‐acting signals located in mRNAs represent higher …

The severe acute respiratory syndrome coronavirus (SARS-CoV) RNA genome is replicated
by a virus-encoded RNA replicase, the key component of which is the nonstructural protein …