Recent developments in natural biopolymer based drug delivery systems

T Fazal, BN Murtaza, M Shah, S Iqbal, M Rehman… - RSC …, 2023 - pubs.rsc.org
Targeted delivery of drug molecules to diseased sites is a great challenge in pharmaceutical
and biomedical sciences. Fabrication of drug delivery systems (DDS) to target and/or …

Challenges associated with penetration of nanoparticles across cell and tissue barriers: a review of current status and future prospects

S Barua, S Mitragotri - Nano today, 2014 - Elsevier
Nanoparticles (NPs) have emerged as an effective modality for the treatment of various
diseases including cancer, cardiovascular and inflammatory diseases. Various forms of NPs …

Mechanisms of drug release in nanotherapeutic delivery systems

PT Wong, SK Choi - Chemical reviews, 2015 - ACS Publications
Targeted drug delivery refers to an established therapeutic strategy that develops platforms
and nanoscale devices for selective delivery of small drug molecules and therapeutic genes …

MMP-responsive 'smart'drug delivery and tumor targeting

Q Yao, L Kou, Y Tu, L Zhu - Trends in pharmacological sciences, 2018 - cell.com
Matrix metalloproteinases (MMPs) are major extracellular enzymes involved in cancer
initiation, progression, and metastasis. MMPs are widely used as cancer biomarkers and …

Matrix Metalloproteinases: A challenging paradigm of cancer management

A Alaseem, K Alhazzani, P Dondapati, S Alobid… - Seminars in cancer …, 2019 - Elsevier
Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases
implicated in a variety of physiological and pathological processes. Over the decades …

In vivo targeted delivery of nanoparticles for theranosis

H Koo, MS Huh, IC Sun, SH Yuk, K Choi… - Accounts of chemical …, 2011 - ACS Publications
Therapy and diagnosis are two major categories in the clinical treatment of disease.
Recently, the word “theranosis” has been created, combining the words to describe the …

Tumor microenvironment targeted nanotherapy

C Fernandes, D Suares, MC Yergeri - Frontiers in pharmacology, 2018 - frontiersin.org
Recent developments in nanotechnology have brought new approaches to cancer
diagnosis and therapy. While enhanced permeability and retention effect promotes nano …

Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery

E Gullotti, Y Yeo - Molecular pharmaceutics, 2009 - ACS Publications
One of the main goals of nanomedicine is to develop a nanocarrier that can selectively
deliver anticancer drugs to the targeted tumors. Extensive efforts have resulted in several …

Polysaccharide–peptide conjugates: a versatile material platform for biomedical applications

HQ Song, Y Fan, Y Hu, G Cheng… - Advanced Functional …, 2021 - Wiley Online Library
Natural polymers, such as polysaccharides and proteins, have been widely studied for
numerous biomedical applications because of their bioactivity, natural origin, and …

Polysaccharide-based conjugates for biomedical applications

A Basu, KR Kunduru, E Abtew, AJ Domb - Bioconjugate chemistry, 2015 - ACS Publications
Polysaccharides contain different functional groups (such as hydroxyl, amino, carboxylic
acid, aldehydes) that make them ideal for conjugation. They are biodegradable …