Human papillomavirus: challenges and opportunities for the control of cervical cancer

P Pina-Sanchez - Archives of Medical Research, 2022 - Elsevier
Viruses are the most abundant and genetically diverse entities on the planet, infect all life
forms and have evolved with their hosts. To date, 263 viral species have been identified that …

Next-generation sequencing in dermatology

AD King, H Deirawan, PA Klein, B Dasgeb… - Frontiers in …, 2023 - frontiersin.org
Over the past decade, Next-Generation Sequencing (NGS) has advanced our
understanding, diagnosis, and management of several areas within dermatology. NGS has …

Efficiency of CIN2+ detection by thyrotropin-releasing hormone (TRH) site-specific methylation

A Chaiwongkot, S Buranapraditkun, S Oranratanaphan… - Viruses, 2023 - mdpi.com
Cervical cancer screening typically involves a Pap smear combined with high-risk human
papillomavirus (hr-HPV) detection. Women with hr-HPV positivity but normal cytology, as …

Cigarette smoking and e-cigarette use induce shared DNA methylation changes linked to carcinogenesis

C Herzog, A Jones, I Evans, JR Raut, M Zikan… - Cancer Research, 2024 - AACR
Tobacco use is a major modifiable risk factor for adverse health outcomes, including cancer,
and elicits profound epigenetic changes thought to be associated with long-term cancer risk …

Tissue Inhibitor of Metalloproteinase 3: Unravelling Its Biological Function and Significance in Oncology

WT Lee, PY Wu, YM Cheng, YF Huang - International journal of molecular …, 2024 - mdpi.com
Tissue inhibitor of metalloproteinases-3 (TIMP3) is vital in regulating several biological
processes. TIMP3 exerts antitumour effects via matrix metalloproteinase (MMP)-dependent …

Bioinformatics analysis of immune characteristics in tumors with alternative carcinogenesis pathways induced by human papillomaviruses

M Smahel, J Nunvar - Virology Journal, 2023 - Springer
Abstract Background Human papillomaviruses (HPVs) induce a subset of head and neck
squamous cell carcinomas (HNSCC) and anogenital cancers, particularly cervical cancer …

Deep learning for predicting prognostic consensus molecular subtypes in cervical cancer from histology images

R Wang, GN Gunesli, VE Skingen, KAF Valen… - npj Precision …, 2025 - nature.com
Cervical cancer remains the fourth most common cancer among women worldwide. This
study proposes an end-to-end deep learning framework to predict consensus molecular …

Nivolumab plus chemoradiotherapy in locally-advanced cervical cancer: the NICOL phase 1 trial

M Rodrigues, G Vanoni, P Loap, C Dubot… - Nature …, 2023 - nature.com
Concurrent chemoradiotherapy (CRT) with blockade of the PD-1 pathway may enhance
immune-mediated tumor control through increased phagocytosis, cell death, and antigen …

Homeobox and Polycomb target gene methylation in human solid tumors

R Blanchett, KH Lau, GP Pfeifer - Scientific Reports, 2024 - nature.com
DNA methylation is an epigenetic mark that plays an important role in defining cancer
phenotypes, with global hypomethylation and focal hypermethylation at CpG islands …

The impact of the tumor microenvironment on the survival of penile cancer patients

S Lohse, JN Mink, L Eckhart, MC Hans, L Jusufi… - Scientific reports, 2024 - nature.com
PeCa is a rare entity with rising incidence rates due to increased infections with human
papillomaviruses (HPV). The distinct subtypes of PeCa with an individual pathogenesis …