The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …

Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

Epithelial–mesenchymal transition (EMT) is a cellular programme that is known to be crucial
for embryogenesis, wound healing and malignant progression. During EMT, cell–cell and …

Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment
(TME) with diverse functions such as extracellular matrix (ECM) remodeling, modulation of …

The presence of lactate in human tumours has been long neglected, confined to the role of a
waste product derived from glycolysis and as a biomarker of malignancy. More recently …

Immune associated cells in the microenvironment have a significant impact on the
development and progression of hepatocellular carcinoma (HCC) and have received more …

Emerging evidence indicate that cancer-associated fibroblasts (CAFs) affect tumor
progression by reshaping the tumor microenvironment. Neutrophils are prominent …

Cancer cells resistance to various therapies remains to be a key challenge nowadays. For a
long time, scientists focused on tumor cells themselves for the mechanisms of acquired drug …

Metastasis is the spread of cancer cells from the primary tumour to distant sites and organs
throughout the body. It is the primary cause of cancer morbidity and mortality, and is …

M2-polarized tumor-associated macrophages (M2-TAMs) infiltrating the tumor
microenvironment contribute to hepatocellular carcinoma (HCC) progression. It was …