Algae synthesise structurally complex glycans to build a protective barrier, the extracellular
matrix. One function of matrix glycans is to slow down microorganisms that try to …

Highlights•Glycosidases carry out many essential functions across all domains of
life.•Activity-based probes can interrogate complex biological samples for glycosidase …

Nucleoside analogs are commonly used in the treatment of cancer and viral infections. Their
syntheses benefit from decades of research but are often protracted, unamenable to …

Covalent inhibitors are experiencing a growing resurgence in drug design and are an
increasingly useful tool in molecular biology. The ability to attach inhibitors to their targets by …

The first synthesis of the protected chain specific to the enacyloxin antibiotic family is
reported. The noticeable features are (a) the construction of the chlorinated …

Glycomimetics are structural mimics of naturally occurring carbohydrates and represent
important therapeutic leads in several disease treatments. However, the structural and …

A set of> 300 nonredundant high-resolution RNA–protein complexes were rigorously
searched for π-contacts between an amino acid side chain (W, H, F, Y, R, E and D) and an …

Carbohydrate/aromatic stacking represents a recurring key motif for the molecular
recognition of glycosides, either by protein binding domains, enzymes, or synthetic …

Biopolymers, like DNA and proteins, fold in specific conformations in order to exert complex
biological functions. Synthetic modifications are commonly used to alter those conformations …

The fucosylation of glycoproteins regulates diverse physiological processes. Inhibitors that
can control cellular levels of protein fucosylation have consequently emerged as being of …