Apicomplexan parasites, such as human malaria parasites, have complex lifecycles
encompassing multiple and diverse environmental niches. Invading, replicating, and …

Malaria causes high levels of morbidity and mortality in human beings worldwide. According
to the World Health Organization (WHO), about half a million people die of this disease each …

Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must
navigate the host skin and vasculature to infect the liver. This journey requires distinct …

Malaria remains one of the most devastating infectious diseases. Reverse genetic screens
offer a powerful approach to identify genes and molecular processes governing malaria …

P. falciparum phenotypic plasticity is linked to the variant expression of clonal multigene
families such as the var genes. We have examined changes in transcription and histone …

Recent reviews (Feachem et al.; Alonso et al.) have concluded that in order to have a
sustainable impact on the global burden of malaria, it is essential that we knowingly reduce …

After being ingested by a female Anopheles mosquito during a bloodmeal on an infected
host, and before they can reach the mosquito salivary glands to be transmitted to a new host …

Malaria elimination may never succeed without the implementation of transmission-blocking
strategies. The transmission of Plasmodium spp. parasites from the human host to the …

Plasmodium falciparum malaria remains a major cause of global morbidity and mortality,
mainly in sub-Saharan Africa. The numbers of new malaria cases and deaths have been …

Our understanding of the structure and regulation of Plasmodium vivax genes is limited by
our inability to grow the parasites in long-term in vitro cultures. Most P. vivax studies must …