Neurotoxicity studies aim at understanding the toxic effects and mechanisms of toxicants to
human central nervous systems (CNS). However, human brains are the most complex …

The adult human brain comprises more than a thousand distinct neuronal and glial cell
types, a diversity that emerges during early brain development. To reveal the precise …

The regulation of fate decisions in progenitor cells lays the foundation for the generation of
neuronal diversity and the formation of specialized circuits with remarkable processing …

Background Melanoma is typically regarded as the most dangerous form of skin cancer.
Although surgical removal of in situ lesions can be used to effectively treat metastatic …

Background Extensive research has established the significant correlations between cancer-
associated fibroblasts (CAFs) and various stages of cancer development, including initiation …

The worldwide prevalence of pancreatic cancer has been rising in recent decades, and its
prognosis has not improved much. The imbalance of substance and energy metabolism in …

The mammalian cerebral cortex contains an extraordinary diversity of cell types that emerge
by implementing different developmental programs. Delineating when and how cellular …

Inhibitory GABAergic interneurons originate in the embryonic medial ganglionic eminence
(MGE) and control network activity in the neocortex. Dysfunction of these cells is believed to …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. To identify
additional genetic factors, we analyzed exome sequences in a large cohort of Chinese ALS …

Inhibition in the mammalian cerebral cortex is mediated by a small population of highly
diverse GABAergic interneurons. These largely local neurons are interspersed among …