[HTML][HTML] Tuning of fed-batch cultivation of Streptomyces clavuligerus for enhanced Clavulanic Acid production based on genome-scale dynamic modeling

D Gómez-Ríos, H Ramírez-Malule, P Neubauer… - Biochemical …, 2022 - Elsevier
Streptomyces clavuligerus (S. clavuligerus) is a filamentous Gram-positive bacterial
producer of the β-lactamase inhibitor clavulanic acid (CA). Antibiotics biosynthesis and …