Recently, increasingly more microsatellites, or simple sequence repeats (SSRs) have been
found and characterized within protein-coding genes and their untranslated regions (UTRs) …

Repeated elements can be widely abundant in eukaryotic genomes, composing more than
50% of the human genome, for example. It is possible to classify repeated sequences into …

Maintenance of proper “labile iron” levels is a critical component in preserving homeostasis.
Iron is a vital element that is a constituent of a number of important macromolecules …

In recent years, it has become increasingly clear that mitochondrial dysfunction and
oxidative damage are major contributors to neuronal loss. Free radicals, typically generated …

The mitochondrion is an essential organelle important for the generation of ATP for cellular
function. This is especially critical for cells with high energy demands, such as neurons for …

Iron has emerged as a significant cause of neurotoxicity in several neurodegenerative
conditions, including Alzheimer's disease (AD), Parkinson's disease (PD), sporadic …

The predominant molecular symptom of aging is the accumulation of altered gene products.
Moreover, several conditions including protein, lipid or glucose oxidation disrupt redox …

Friedreich ataxia (FRDA) is caused by a homozygous GAA repeat expansion mutation within
intron 1 of the FXN gene, leading to reduced expression of frataxin protein. Evidence …

Friedreich ataxia (FRDA) is an autosomal-recessive disorder characterized by progressive
neurological and cardiac abnormalities. It predominantly affects individuals of European and …

Gene repression is crucial to the maintenance of differentiated cell types in multicellular
organisms, whereas aberrant silencing can lead to disease. The organization of DNA into …