The blood–brain barrier (BBB) is an important physiological barrier that separates the
central nervous system (CNS) from the peripheral circulation, which contains inflammatory …

Our body keeps separating the toxic chemicals in the blood from the brain. A significant
number of drugs do not enter the central nervous system (CNS) due to the blood-brain …

Intracerebral hemorrhage (ICH) is a devastating form of stroke affecting millions of people
worldwide. Parenchymal hematoma triggers a series of reactions leading to primary and …

Intracranial aneurysm subarachnoid hemorrhage (SAH) is a cerebrovascular disorder
associated with high overall mortality. Currently, the underlying mechanisms of pathological …

Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and disability but
no specific or effective treatment. In the last two decades, much has been learned about the …

Abstract Background and Aims In experimental models, enhanced inflammation contributes
to secondary brain injury in spontaneous intracerebral hemorrhage (ICH). Several …

B cells, also known as B lymphocytes or lymphoid lineage cells, are a historically
understudied cell population with regard to brain-related injuries and diseases. However, an …

Aneurysmal subarachnoid hemorrhage (aSAH) is one of the most severe neurological
disorders, with a high mortality rate and severe disabling functional sequelae. Systemic …

Hydrocephalus is a common complication of aneurysmal subarachnoid hemorrhage (aSAH)
and reportedly contributes to poor neurological outcomes. In this review, we summarize the …

Stroke disrupts the homeostatic balance within the brain and is associated with a significant
accumulation of necrotic cellular debris, fluid, and peripheral immune cells in the central …