Crosstalk between apoptosis and autophagy: molecular mechanisms and therapeutic strategies in cancer
A El-Khattouti, D Selimovic, Y Haikel… - Journal of cell …, 2013 - journals.sagepub.com
Both apoptosis and autophagy are highly conserved processes that besides their role in the
maintenance of the organismal and cellular homeostasis serve as a main target of tumor …
maintenance of the organismal and cellular homeostasis serve as a main target of tumor …
NF-κB-modulated miR-130a targets TNF-α in cervical cancer cells
J Zhang, H Wu, P Li, Y Zhao, M Liu, H Tang - Journal of translational …, 2014 - Springer
Background Nuclear factor-κB (NF-κB) induces a variety of biological processes through
transcriptional gene control whose products are components in various signaling pathways …
transcriptional gene control whose products are components in various signaling pathways …
Cellular immunotherapy for pediatric solid tumors
Substantial progress has been made in the treatment of pediatric solid tumors over the past
4 decades. However, children with metastatic and or recurrent disease continue to do poorly …
4 decades. However, children with metastatic and or recurrent disease continue to do poorly …
Blocks to thyroid cancer cell apoptosis can be overcome by inhibition of the MAPK and PI3K/AKT pathways
V Gunda, O Bucur, J Varnau, P Vanden Borre… - Cell death & …, 2014 - nature.com
Current treatment for recurrent and aggressive/anaplastic thyroid cancers is ineffective.
Novel targeted therapies aimed at the inhibition of the mutated oncoprotein BRAF V600E …
Novel targeted therapies aimed at the inhibition of the mutated oncoprotein BRAF V600E …
Kaempferol sensitizes tumor necrosis factor-related apoptosis-inducing ligand-resistance chronic myelogenous leukemia cells to apoptosis
R Saraei, HS Rahman, M Soleimani… - Molecular Biology …, 2022 - Springer
Background The tumor necrosis factor (TNF)-related apoptosis-inducing ligand, TRAIL, an
apoptosis-inducing cytokine, has attracted much attention in the treatment of cancer for its …
apoptosis-inducing cytokine, has attracted much attention in the treatment of cancer for its …
Bay 61-3606 sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells
SY Kim, SE Park, SM Shim, S Park, KK Kim, SY Jeong… - PLoS …, 2015 - journals.plos.org
Breast cancer cells generally develop resistance to TNF-Related Apoptosis-Inducing Ligand
(TRAIL) and, therefore, assistance from sensitizers is required. In our study, we have …
(TRAIL) and, therefore, assistance from sensitizers is required. In our study, we have …
Resistance to TRAIL in mantle cell lymphoma cells is associated with the decreased expression of purine metabolism enzymes
J Pospisilova, O Vit, L Lorkova… - International …, 2013 - spandidos-publications.com
Mantle cell lymphoma (MCL) is a rare aggressive type of B-cell non-Hodgkin's lymphoma.
Response to chemotherapy tends to be short and virtually all patients sooner or later …
Response to chemotherapy tends to be short and virtually all patients sooner or later …
Reactive oxygen species contribute to TRAIL receptors upregulation; the mechanism for PH II-7 augmenting TRAIL induced apoptosis in leukemia cells
H Peng, X Yuan, S Luo, F Li, X Wei, Z Ye… - European Journal of …, 2015 - Elsevier
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce
apoptosis in cancer cells and is verified to be effective in various cancers. However, a variety …
apoptosis in cancer cells and is verified to be effective in various cancers. However, a variety …
Death Receptors 4 and 5 and Idiopathic Pulmonary Fibrosis
S Miller - 2016 - conservancy.umn.edu
Idiopathic pulmonary fibrosis (IPF) is an irreversible lethal interstitial lung disease with an
unknown cause, killing about 40,000 people per year. In IPF, lung fibroblasts become …
unknown cause, killing about 40,000 people per year. In IPF, lung fibroblasts become …