[HTML][HTML] Advancements, challenges and future perspectives on peptide-based drugs: Focus on antimicrobial peptides

X Luo, H Chen, Y Song, Z Qin, L Xu, N He, Y Tan… - European Journal of …, 2023 - Elsevier
Among other health related issues, the rising concerns on drug resistance led to look for
alternative pharmaceutical drugs that are effective both against infectious and noninfectious …

Melittin-based nano-delivery systems for cancer therapy

A Wang, Y Zheng, W Zhu, L Yang, Y Yang, J Peng - Biomolecules, 2022 - mdpi.com
Melittin (MEL) is a 26-amino acid polypeptide with a variety of pharmacological and
toxicological effects, which include strong surface activity on cell lipid membranes, hemolytic …

Optimization of the hemolysis assay for the assessment of cytotoxicity

IP Sæbø, M Bjørås, H Franzyk, E Helgesen… - International journal of …, 2023 - mdpi.com
In vitro determination of hemolytic properties is a common and important method for
preliminary evaluation of cytotoxicity of chemicals, drugs, or any blood-contacting medical …

Gramicidin S and melittin: Potential anti-viral therapeutic peptides to treat SARS-CoV-2 infection

MG Enayathullah, Y Parekh, S Banu, S Ram… - Scientific Reports, 2022 - nature.com
The COVID19 pandemic has led to multipronged approaches for treatment of the disease.
Since de novo discovery of drugs is time consuming, repurposing of molecules is now …

Neuroprotective Activity of Melittin—The Main Component of Bee Venom—Against Oxidative Stress Induced by Aβ25–35 in In Vitro and In Vivo Models

CD Nguyen, G Lee - Antioxidants, 2021 - mdpi.com
Melittin, a 26-amino acid peptide, is the main component of the venom of four honeybee
species and exhibits neuroprotective actions. However, it is unclear how melittin ameliorates …

No country for old antibiotics! Antimicrobial peptides (AMPs) as next-generation treatment for skin and soft tissue infection

M Răileanu, R Borlan, A Campu, L Janosi… - International Journal of …, 2023 - Elsevier
In recent years, the unprecedented rise of bacterial antibiotic resistance together with the
lack of adequate therapies have made the treatment of skin infections and chronic wounds …

A novel designed membrane-active peptide for the control of foodborne Salmonella enterica serovar Typhimurium

S Sengkhui, N Klubthawee, R Aunpad - Scientific Reports, 2023 - nature.com
The main cause of non-typhoidal Salmonella (NTS) infection in humans is ingestion of
contaminated animal-derived foods such as eggs, poultry and dairy products. These …

A target-based discovery from a parasitic helminth as a novel therapeutic approach for autoimmune diseases

Y Ni, R Xiong, Y Zhu, N Luan, C Yu, K Yang, H Wang… - …, 2023 - thelancet.com
Summary Background Regulatory T cells (Tregs) can alleviate the development of
autoimmune and inflammatory diseases, thereby proposing their role as a new therapeutic …

Antibiofilm effect of melittin alone and in combination with conventional antibiotics toward strong biofilm of MDR-MRSA and -Pseudomonas aeruginosa

R Mirzaei, H Esmaeili Gouvarchin Ghaleh… - Frontiers in …, 2023 - frontiersin.org
Introduction Multidrug-resistant (MDR) pathogens are being recognized as a critical threat to
human health if they can form biofilm and, in this sense, biofilm-forming MDR-methicillin …

Chemical composition and antimicrobial properties of honey bee venom

V Isidorov, A Zalewski, G Zambrowski, I Swiecicka - Molecules, 2023 - mdpi.com
Due to its great medical and pharmaceutical importance, honey bee venom is considered to
be well characterized both chemically and in terms of biomedical activity. However, this …