[HTML][HTML] Human gut microbiota in health and disease: Unveiling the relationship

M Afzaal, F Saeed, YA Shah, M Hussain… - Frontiers in …, 2022 - frontiersin.org
The human gut possesses millions of microbes that define a complex microbial community.
The gut microbiota has been characterized as a vital organ forming its multidirectional …

[HTML][HTML] Understanding the role of the gut microbiome in gastrointestinal cancer: A review

D Ağagündüz, E Cocozza, Ö Cemali… - Frontiers in …, 2023 - frontiersin.org
Gastrointestinal cancer represents one of the most diagnosed types of cancer. Cancer is a
genetic and multifactorial disease, influenced by the host and environmental factors. It has …

[HTML][HTML] Physical activity and sports—real health benefits: a review with insight into the public health of Sweden

C Malm, J Jakobsson, A Isaksson - Sports, 2019 - mdpi.com
Positive effects from sports are achieved primarily through physical activity, but secondary
effects bring health benefits such as psychosocial and personal development and less …

[HTML][HTML] Dual role of microbiota-derived short-chain fatty acids on host and pathogen

R Mirzaei, E Dehkhodaie, B Bouzari, M Rahimi… - Biomedicine & …, 2022 - Elsevier
A growing body of documents shows microbiota produce metabolites such as short-chain
fatty acids (SCFAs) as crucial executors of diet-based microbial influence the host and …

[HTML][HTML] Microbiome in colorectal cancer: how to get from meta-omics to mechanism?

D Ternes, J Karta, M Tsenkova, P Wilmes, S Haan… - Trends in …, 2020 - cell.com
Mounting evidence from metagenomic analyses suggests that a state of pathological
microbial imbalance or dysbiosis is prevalent in the gut of patients with colorectal cancer …

A microengineered collagen scaffold for generating a polarized crypt-villus architecture of human small intestinal epithelium

Y Wang, DB Gunasekara, MI Reed, M DiSalvo… - Biomaterials, 2017 - Elsevier
The human small intestinal epithelium possesses a distinct crypt-villus architecture and
tissue polarity in which proliferative cells reside inside crypts while differentiated cells are …

Organ‐on‐chip models: implications in drug discovery and clinical applications

R Mittal, FW Woo, CS Castro, MA Cohen… - Journal of cellular …, 2019 - Wiley Online Library
Before a lead compound goes through a clinical trial, preclinical studies utilize two‐
dimensional (2D) in vitro models and animal models to study the pharmacodynamics and …

[HTML][HTML] Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer

X Wu, Y Wu, L He, L Wu, X Wang, Z Liu - Journal of Cancer, 2018 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is one of the major health threats in developed countries. Changes
in dietary components, such as more protein and lipid intake, can increase the risk of CRC …

Synthetic ecology of the human gut microbiota

G Vrancken, AC Gregory, GRB Huys, K Faust… - Nature Reviews …, 2019 - nature.com
Despite recent advances in sequencing and culturing, a deep knowledge of the wiring and
functioning of the human gut ecosystem and its microbiota as a community is still missing. A …

Role of SCFAs in gut microbiome and glycolysis for colorectal cancer therapy

G Wang, Y Yu, YZ Wang, JJ Wang… - Journal of cellular …, 2019 - Wiley Online Library
Increased risk of colorectal cancer (CRC) is associated with altered intestinal microbiota as
well as short‐chain fatty acids (SCFAs) reduction of output The energy source of colon cells …