Molecular dynamics simulations have evolved into a mature technique that can be used
effectively to understand macromolecular structure-to-function relationships. Present …

Allostery is a ubiquitous biological regulatory process in which distant binding sites within a
protein or enzyme are functionally and thermodynamically coupled. Allosteric interactions …

Benzotriazole UV stabilizers (BZTs) belong to one prominent group of ultraviolet (UV)
stabilizers and are widely used in various plastics materials. Their large production volumes …

Hydrate reserves play a crucial role in energy storage and resources across the world. Gas
hydrate formation may lead to various forms of blockages in oil/gas production and …

Gene therapy is one of the most effective strategies for cancer treatment. The p53 protein,
commonly known as the “guardian of the genome”, plays a critical role in gene activation …

The p53 protein is a tumor suppressor crucial for cell cycle and genome integrity. In a very
large proportion of human cancers, p53 is frequently inactivated by mutations located in its …

The interaction between thiamine hydrochloride (TA) and bovine serum albumin (BSA) was
investigated by fluorescence, FTIR, UV–vis spectroscopic and cyclic voltammetric …

Significance: Increased plasma concentrations of total homocysteine (tHcy; mild-moderate
hyperhomocysteinemia: 15–50 μ M tHcy) are considered an independent risk factor for the …

Application of computational tools and techniques has emerged as an invincible instrument
to unravel the structure-function relationship and offered better mechanistic insights in the …

Prion diseases are associated with the misfolding of the normal helical cellular form of prion
protein (PrP C) into the β-sheet-rich scrapie form (PrP Sc) and the subsequent aggregation …