Activation of endothelium and immune cells is fundamental to the initiation of autoimmune
diseases such as rheumatoid arthritis (RA), and it results in trans-endothelial cell migration …

Metformin is a first-line therapeutic agent for type 2 diabetes. Apart from its glucose-lowering
effect, metformin is attracting interest regarding possible therapeutic benefits in various other …

Background: Paclitaxel-induced peripheral neuropathy (PN) is a serious clinical problem
with no approved drug for prevention. This study aimed to examine the neuroprotective …

Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disorder characterized by
itching and eczematous lesions. It is often associated with a personal or familial history of …

Autoimmune diseases (AIDs) refer to connective tissue inflammation caused by aberrant
autoantibodies resulting from dysfunctional immune surveillance. Most of the current …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by
neovascularization, immune cell infiltration, and synovial hyperplasia, which leads to …

Hyperinsulinemia, hyperglycemia, and chronic inflammation may play a role in
hepatocellular carcinoma (HCC). Treatment of HCC patients with the antidiabetic medication …

Over the past few decades, the connection between metabolism and various inflammatory
and rheumatic diseases has been an area of active investigation. Nonetheless, the precise …

Background The overproliferation of fibroblast-like synoviocytes (FLS) contributes to
synovial hyperplasia, a pivotal pathological feature of rheumatoid arthritis (RA). Shikonin …

Several studies have shown that rheumatologic patients can benefit from metformin, but it
remains unclear whether metformin treatment is causally associated with the risk of …