Intervertebral disc (IVD) degeneration is a major contributing factor for discogenic low back
pain (LBP), causing a significant global disability. The IVD consists of an inner core …

Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder
that results in major social and economic burdens. Recent research has identified …

Intervertebral disc degeneration is a major cause of low back pain. Despite its long history
and large socio-economical impact in western societies, the initiation and progress of disc …

Degeneration of the intervertebral discs (IVDs) is a major contributor to back, neck and
radicular pain. IVD degeneration is characterized by increases in levels of the …

Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a
problem with a heavy economic burden, which has been increasing in prevalence as …

OBJECTIVE: To develop evidence-based clinical practice guidelines for interventional
techniques in the diagnosis and treatment of chronic spinal pain. METHODOLOGY …

Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation,
and survival of sympathetic and sensory afferent neurons during development. A substantial …

Chronic low back pain (CLBP), lasting> 3 months, is the end result of multiple pathogenic
factors. Unfortunately, little is known about CLBP pathogenesis, which limits its …

BACKGROUND: Intervertebral disc (IVD) degeneration remains a clinically important
condition for which treatment is costly and relatively ineffective. The molecular basis of …

Objective Back pain is an elusive symptom complicated by a variety of possible causes,
precipitating and maintaining factors, and consequences. Notably, the underlying pathology …