Antibodies play an essential role in host defence against pathogens by recognizing
microorganisms or infected cells. Although preventing pathogen entry is one potential …

Natural killer (NK) cells are important effectors of innate immunity playing a key role in the
eradication and clearance of viral infections. Over the recent years, several studies have …

The Fc region of HIV-1 Env-specific broadly neutralizing antibodies (bNAbs) is required for
suppressing viraemia, through mechanisms which remain poorly understood. Here, we …

One of the top research priorities of the international AIDS society by the action “Towards an
HIV Cure” is the purge or the decrease of the pool of all latently infected cells. This strategy …

A considerable body of evidence suggests that Fc-dependent functions improve the capacity
of broadly neutralizing antibodies (BnAbs) to protect against and control HIV-1 infection. This …

Introduction of cART in 1996 has drastically increased the life expectancy of people living
with HIV-1. However, this treatment has not allowed cure as cessation of cART is associated …

Combined antiretroviral therapy (cART) has been successful in prolonging lifespan and
reducing mortality of patients infected with human immunodeficiency virus (HIV). However …

HIV-1 is a retrovirus that integrates into host chromatin and can remain transcriptionally
quiescent in a pool of immune cells. This characteristic enables HIV-1 to evade both host …

Lifelong antiretroviral therapy (ART) for HIV-1 does not diminish the established latent
reservoir. A possible cure approach is to reactivate the quiescent genome from latency and …

The correlation of HIV-specific antibody-dependent cellular cytotoxicity (ADCC) responses
with protection from and delayed progression of HIV-1 infection provides a rationale to …