Malignant cells are part of a complex network within the tumor microenvironment, where
their interaction with host cells and soluble mediators, including complement components, is …

The complement system plays crucial roles in both innate and adaptive immune responses,
facilitating the elimination of pathogens such as microorganisms and damaged cells …

The complement system, a key component of innate immunity, is involved in seemingly
contradictory aspects of tumor progression and cancer therapy. It can act as an immune …

Ground-breaking awareness has been reached about the intricate and dynamic connection
between developing tumors and the host immune system. Being a powerful arm of innate …

Cancer remains a formidable global health challenge requiring the continued exploration of
innovative therapeutic approaches. While traditional treatment strategies including surgery …

Complement C4 is a key component in the activation of classical and lectin complement
pathways, which are observed in both animal tumor models and cancer patients. While its …

Introduction Lupus nephritis (LN) is a disease marked by autoantibodies against
complement components. Autoantibodies against negative complement regulator factor H …

Purpose We observed that the tumor microenvironment (TME) in metastatic epithelial
ovarian cancer (EOC) and in other solid tumors can reprogram normal neutrophils to acquire …

The complement system is an immune surveillance system activated by recognizing
structures lacking complement regulators. It is also triggered by pathogen associated …