Normal and leukemic stem cell niches: insights and therapeutic opportunities

K Schepers, TB Campbell, E Passegué - Cell stem cell, 2015 - cell.com
Hematopoietic stem cells (HSCs) rely on instructive cues from the bone marrow (BM) niche
to maintain their quiescence and adapt blood production to the organism's needs …

Mesenchymal stem cell: keystone of the hematopoietic stem cell niche and a stepping-stone for regenerative medicine

PS Frenette, S Pinho, D Lucas… - Annual review of …, 2013 - annualreviews.org
Mesenchymal stem cells (MSCs) are self-renewing precursor cells that can differentiate into
bone, fat, cartilage, and stromal cells of the bone marrow. Recent studies suggest that MSCs …

Bone marrow‐on‐a‐chip: Long‐term culture of human haematopoietic stem cells in a three‐dimensional microfluidic environment

S Sieber, L Wirth, N Cavak… - Journal of tissue …, 2018 - Wiley Online Library
Multipotent haematopoietic stem and progenitor cells (HSPCs) are the source for all blood
cell types. The bone marrow stem cell niche in which the HSPCs are maintained is known to …

HSC niche biology and HSC expansion ex vivo

S Kumar, H Geiger - Trends in molecular medicine, 2017 - cell.com
Hematopoietic stem cell (HSC) transplantation can restore a new functional hematopoietic
system in recipients in cases where the system of the recipient is not functional or for …

[HTML][HTML] Current insights into the bone marrow niche: From biology in vivo to bioengineering ex vivo

Y Xiao, CAS McGuinness, WS Doherty-Boyd… - Biomaterials, 2022 - Elsevier
Hematopoietic stem cells (HSCs) are fundamental to the generation of the body's blood and
immune cells. They reside primarily within the bone marrow (BM) niche microenvironment …

Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches

A Abarrategi, SA Mian, D Passaro… - Journal of Experimental …, 2018 - rupress.org
Xenotransplantation of patient-derived samples in mouse models has been instrumental in
depicting the role of hematopoietic stem and progenitor cells in the establishment as well as …

[HTML][HTML] Self-renewing human bone marrow mesenspheres promote hematopoietic stem cell expansion

J Isern, B Martín-Antonio, R Ghazanfari, AM Martín… - Cell reports, 2013 - cell.com
Strategies for expanding hematopoietic stem cells (HSCs) include coculture with cells that
recapitulate their natural microenvironment, such as bone marrow stromal stem/progenitor …

Mesenchymal stem cell-based therapy

V Mundra, IC Gerling, RI Mahato - Molecular pharmaceutics, 2013 - ACS Publications
Mesenchymal stem cells (MSCs) are multipotent adult stem cells which have self-renewal
capacity and differentiation potential into several mesenchymal lineages including bones …

A review of gradient stiffness hydrogels used in tissue engineering and regenerative medicine

T Xia, W Liu, L Yang - … of Biomedical Materials Research Part A, 2017 - Wiley Online Library
Substrate stiffness is known to impact characteristics including cell differentiation,
proliferation, migration and apoptosis. Hydrogels are polymeric materials distinguished by …

Engineering the hematopoietic stem cell niche: Frontiers in biomaterial science

JS Choi, BP Mahadik, BAC Harley - Biotechnology journal, 2015 - Wiley Online Library
Hematopoietic stem cells (HSCs) play a crucial role in the generation of the body's blood
and immune cells. This process takes place primarily in the bone marrow in …