BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely
acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes …

The Bromodomain and Extra-Terminal Domain (BET) family of proteins is characterized by
the presence of two tandem bromodomains and an extra-terminal domain. The mammalian …

Infection with Merkel cell polyomavirus (MCPyV) can lead to Merkel cell carcinoma (MCC), a
lethal form of skin cancer. However, the skin cell type productively infected by MCPyV …

Double-strand breaks (DSBs) are one of the most toxic forms of DNA damage and represent
a major source of genomic instability. Members of the bromodomain and extra-terminal …

Transcription is a highly dynamic process that generates single-stranded DNA (ssDNA) in
the genome as 'transcription bubbles'. Here we describe a kethoxal-assisted single-stranded …

BET proteins commonly activate cellular gene expression, yet inhibiting their recruitment
paradoxically reactivates latent HIV-1 transcription. Here we identify the short isoform of BET …

The pluripotent state of embryonic stem cells (ESCs) is defined by its transcriptome and
epigenome. The chromatin reader Brd4 determines ESC identity. Although Brd4 regulation …

The COVID-19 pandemic poses a serious global health threat. The rapid global spread of
SARS-CoV-2 highlights an urgent need to develop effective therapeutics for blocking SARS …

Abstract Bromodomain‐containing 4 (BRD4), a member of Bromo and Extra‐Terminal (BET)
family, recognizes acetylated histones and is of importance in transcription, replication, and …

Proper temporal epigenetic regulation of gene expression is essential for cell fate
determination and tissue development. The Bromodomain-containing Protein-4 (BRD4) was …