Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …

Immune checkpoint inhibitors (ICIs) have transformed the treatment paradigm for solid
tumors. However, even in cancers generally considered ICI-sensitive, responses can vary …

Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, with 20%
of patients presenting with metastatic disease at diagnosis. TGF-β signaling plays a crucial …

Survival in mismatch-repair proficient (MMRp) metastatic colorectal cancer (mCRC) remains
poor and chemotherapy is the mainstay of treatment. Immunotherapy has demonstrated …

BACKGROUND Improving and predicting tumor response to immunotherapy remains
challenging. Combination therapy with a transforming growth factor-β receptor (TGF-βR) …

TGFβ is a pleiotropic signaling pathway that plays a pivotal role in regulating a multitude of
cellular functions. TGFβ has a dual role in cell regulation where it induces growth inhibition …

Simple Summary The implementation of immunotherapy in the therapeutic landscape of
colorectal carcinoma has been difficult due to the inefficacy reported in early clinical trials …

Despite significant advances in the surgical and systemic therapy of colorectal cancer (CRC)
in recent decades, recurrence rates remain high. Apart from microsatellite instability status …

Mismatch repair proficient (MMRp) tumors of colorectal origin are one of the prevalent yet
unpredictable clinical challenges. Despite earnest efforts, optimal treatment modalities have …

Over the past decade, our understanding of the diversity of colorectal cancer has expanded
significantly, raising hopes of tailoring treatments more precisely for individual patients. A …