Regulatory T-cells (T reg) protect the host from autoimmune disease by suppressing self-
reactive immune cells. As such, T reg may also block antitumor immune responses. Recent …

Mice with targeted disruptions of the transforming growth factor-β1 (TGF-β1) gene or TGF-β1
intracellular signalling pathways develop intestinal inflammation. Conversely, TGF-β1 …

Rationale: Pulmonary arterial hypertension (PAH) is an incurable disease associated with
viral infections and connective tissue diseases. The relationship between inflammation and …

Chronic inflammatory diseases may develop when regulatory T cells (Tregs) fail to control
the balance between tolerance and immunity. Alternatively, activated immune cells might …

Immunity to collagen V [col (V)] contributes to lung 'rejection.'We hypothesized that ischemia
reperfusion injury (IRI) associated with lung transplantation unmasks antigenic col (V) such …

TGF-β is a pleiotropic cytokine with powerful immunosuppressive functions. Mice deficient
for TGF-β1 show a dramatic phenotype with severe multiorgan inflammation and die shortly …

Immunosuppressants are powerful drugs, capable of triggering severe adverse effects.
Hence, there is tremendous interest in replacing them with less‐toxic agents. Adoptive …

Lung transplantation is the only definitive treatment modality for many forms of end-stage
lung disease. However, the lung is rejected more often than any other type of solid organ …

Autoreactive CD4+ T lymphocytes play a vital role in the pathogenesis of multiple sclerosis
and its animal model, experimental autoimmune encephalomyelitis. Since the discovery of T …

Rationale: The pathogenesis of primary graft dysfunction (PGD), a serious complication of
lung transplantation, is poorly understood. Human studies and rodent models have shown …