Metabolic engineering has allowed the production of a diverse number of valuable
chemicals using microbial organisms. Many biological challenges for improving bio …

Dynamic pathway engineering aims to build metabolic production systems embedded with
intracellular control mechanisms for improved performance. These control systems enable …

Metabolite biosensors are central to current efforts toward precision engineering of
metabolism. Although most research has focused on building new biosensors, their …

Advances in metabolic engineering have led to the synthesis of a wide variety of valuable
chemicals in microorganisms. The key to commercializing these processes is the …

Recent advances in synthetic biology have enabled the construction of molecular circuits
that operate across multiple scales of cellular organization, such as gene regulation …

Phenotypic variation is a hallmark of cellular physiology. Metabolic heterogeneity, in
particular, underpins single-cell phenomena such as microbial drug tolerance and growth …

Recent progress in synthetic biology allows the construction of dynamic control circuits for
metabolic engineering. This technology promises to overcome many challenges …

Bacteria can be harnessed to synthesise high-value chemicals. A promising strategy for
increasing productivity uses inducible control systems to switch metabolism from growth to …

Division of labor between cells is ubiquitous in biology but the use of multicellular consortia
for engineering applications is only beginning to be explored. A significant advantage of …

Two-component systems (TCSs) sensing and responding to various stimuli outside and
inside cells are valuable resources for developing biosensors with synthetic biology …