Organisms of all phyla express mechanosensitive ion channels with a wide range of
physiological functions. In recent years, several classes of mechanically gated ion channels …

Sound-induced mechanical stimuli are detected by elaborate mechanosensory transduction
(MT) machinery in highly specialized hair cells of the inner ear. Genetic studies of inherited …

The initial step in the sensory transduction pathway underpinning hearing and balance in
mammals involves the conversion of force into the gating of a mechanosensory transduction …

Summary Transmembrane channel-like (TMC) 1 and 2 are required for the
mechanotransduction of mouse inner ear hair cells and localize to the site of …

Hundreds of neurotoxic insecticides are currently in use. However, only a few direct targets
have been identified. Here, using Drosophila and the insecticide flonicamid, we identified …

Summary TMC1 and TMC2 (TMC1/2) have been proposed to form the pore of the
mechanotransduction channel of cochlear hair cells. Here, we show that TMC1/2 cannot …

Purification of membrane proteins for biochemical and structural studies is commonly
achieved by recombinant overexpression in heterologous cell lines. However, many …

Mechanotransduction channels have been proposed as force sensors in various
physiological processes, such as hearing and touch. In particular, TMC1 has been shown to …

Phasic (fast) and tonic (sustained) inhibition of γ-aminobutyric acid (GABA) are fundamental
for regulating day-to-day activities, neuronal excitability, and plasticity. However, the …

Glia are typically considered as supporting cells for neural development and synaptic
transmission. Here, we report an active role of a glia in olfactory transduction. As a …