CRNDE: a long non-coding RNA involved in C ance R, N eurobiology, and DE velopment

BC Ellis, PL Molloy, LD Graham - Frontiers in genetics, 2012 - frontiersin.org
CRNDE is the gene symbol for Colorectal Neoplasia Differentially Expressed (non-protein-
coding), a long non-coding RNA (lncRNA) gene that expresses multiple splice variants and …

[HTML][HTML] Mnk kinase pathway: Cellular functions and biological outcomes

S Joshi, LC Platanias - World journal of biological chemistry, 2014 - ncbi.nlm.nih.gov
The mitogen-activated protein kinase (MAPK) interacting protein kinases 1 and 2 (Mnk1 and
Mnk2) play important roles in controlling signals involved in mRNA translation. In addition to …

CRNDE, a long-noncoding RNA, promotes glioma cell growth and invasion through mTOR signaling

Y Wang, Y Wang, J Li, Y Zhang, H Yin, B Han - Cancer letters, 2015 - Elsevier
The transcripts of the gene Colorectal Neoplasia Differentially Expressed (CRNDE) are
recognized as long-noncoding RNAs (lncRNAs), which are expressed in specific regions …

Brain tumor cells in circulation are enriched for mesenchymal gene expression

JP Sullivan, BV Nahed, MW Madden, SM Oliveira… - Cancer discovery, 2014 - AACR
Glioblastoma (GBM) is a highly aggressive brain cancer characterized by local invasion and
angiogenic recruitment, yet metastatic dissemination is extremely rare. Here, we adapted a …

Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3

N Robichaud, SV del Rincon, B Huor, T Alain… - Oncogene, 2015 - nature.com
The progression of cancers from primary tumors to invasive and metastatic stages accounts
for the overwhelming majority of cancer deaths. Understanding the molecular events which …

Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data

HW Cheng, YH Liang, YL Kuo, CP Chuu, CY Lin… - Cell death & …, 2015 - nature.com
Glioblastoma (GBM) is a common and malignant tumor with a poor prognosis. Glioblastoma
stem cells (GSCs) have been reported to be involved in tumorigenesis, tumor maintenance …

[HTML][HTML] Long non-coding RNA in glioma: signaling pathways

J Shi, B Dong, J Cao, Y Mao, W Guan, Y Peng… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Glioma is regarded as the most prevalent malignant carcinoma of the central nervous
system. Thus, the development of new therapeutic strategies targeting glioma is of …

Mnks, eIF4E phosphorylation and cancer

CG Proud - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2015 - Elsevier
The MAP kinase signal-integrating kinases or MAP kinase-interacting protein kinases
(Mnks) are activated by signaling through the oncogenic MAP kinase (ERK) pathway. The …

Role of CD14 in human disease

D Sharygin, LG Koniaris, C Wells, TA Zimmers… - …, 2023 - Wiley Online Library
The cell surface antigen CD14 is primarily understood to act as a co‐receptor for toll‐like
receptors (TLRs) to activate innate immunity responses to pathogens and tissue injury in …

The role of the eukaryotic translation initiation factor 4E (eIF4E) in neuropsychiatric disorders

IS Amorim, G Lach, CG Gkogkas - Frontiers in genetics, 2018 - frontiersin.org
Protein synthesis in eukaryotic cells is a complex, multi-step and tightly regulated process.
Translation initiation, the rate limiting step in protein synthesis, is dependent on the activity of …