As the median age of the population increases, the number of individuals with Alzheimer's
disease (AD) and the associated socio-economic burden are predicted to worsen. While …

Whilst being environmentally abundant, aluminum is not essential for life. On the contrary,
aluminum is a widely recognized neurotoxin that inhibits more than 200 biologically …

Background. Cholinesterases are a group of serine hydrolases that split the neurotransmitter
acetylcholine (ACh) and terminate its action. Of the two types, butyrylcholinesterase and …

Neurodegeneration describes the loss of neuronal structure and function. Numerous
neurodegenerative diseases are associated with neurodegeneration. Many are rare and …

The brain is a highly compartmentalized organ exceptionally susceptible to accumulation of
metabolic errors. Alzheimer's disease (AD) is the most prevalent neurodegenerative disease …

A meta-analysis was performed to investigate whether chronic exposure to aluminum (Al) is
associated with increased risk of Alzheimer's disease (AD). Eight cohort and case-control …

Amyloids can have normal biological functions. 1r3 However, amyloidogenic proteins can
also form unwanted oligomeric or polymeric aggregates when disturbed from their native …

Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …

Alzheimer's disease (AD) is the most common, age-dependent neurodegenerative disorder.
While AD has been intensively studied from different aspects, there is no effective cure for …

Trace elements and metals play critical roles in the normal functioning of the central nervous
system (CNS), and their dysregulation has been implicated in neurodegenerative disorders …