The role of bone marrow microenvironment (BMM) cells in acute myeloid leukemia (AML) progression: immune checkpoints, metabolic checkpoints, and signaling …
M Bakhtiyari, M Liaghat, F Aziziyan… - Cell Communication and …, 2023 - Springer
Acute myeloid leukemia (AML) comprises a multifarious and heterogeneous array of
illnesses characterized by the anomalous proliferation of myeloid cells in the bone marrow …
illnesses characterized by the anomalous proliferation of myeloid cells in the bone marrow …
The development of small-molecule modulators for ClpP protease activity
The global spread of antibiotic resistance among important human pathogens emphasizes
the need to find new antibacterial drugs with a novel mode of action. The ClpP protease has …
the need to find new antibacterial drugs with a novel mode of action. The ClpP protease has …
Human ClpP protease, a promising therapy target for diseases of mitochondrial dysfunction
B Luo, Y Ma, YZ Zhou, N Zhang, Y Luo - Drug discovery today, 2021 - Elsevier
Human caseinolytic protease P (Hs ClpP), an ATP-dependent unfolding peptidase protein in
the mitochondrial matrix, controls protein quality, regulates mitochondrial metabolism, and …
the mitochondrial matrix, controls protein quality, regulates mitochondrial metabolism, and …
The capacity of long-term in vitro proliferation of acute myeloid leukemia cells supported only by exogenous cytokines is associated with a patient subset with adverse …
AK Brenner, E Aasebø, M Hernandez-Valladares… - Cancers, 2019 - mdpi.com
Acute myeloid leukemia (AML) is an aggressive malignancy, which is highly heterogeneous
with regard to chemosensitivity and biological features. The AML cell population is …
with regard to chemosensitivity and biological features. The AML cell population is …
Cell intrinsic and extrinsic regulation of leukemia cell metabolism
Metabolic homeostasis is a fundamental property of cells that becomes dysregulated in
cancer to meet the altered, often heightened, demand for metabolism for increased growth …
cancer to meet the altered, often heightened, demand for metabolism for increased growth …
Detecting subnetwork-level dynamic correlations
Y Yan, S Qiu, Z Jin, S Gong, Y Bai, J Lu, T Yu - Bioinformatics, 2017 - academic.oup.com
Motivation The biological regulatory system is highly dynamic. The correlations between
many functionally related genes change over different biological conditions. Finding …
many functionally related genes change over different biological conditions. Finding …
PURIFICATION OF THE CASEINOLYTIC CLP PROTEASE COMPLEX
LP Manzanares - 2022 - zaguan.unizar.es
The caseinolytic protease P (ClpP) is an essential protein for bacteria and bacterial derived
organelles. It belongs to the AAA+ family of proteases and has proteolytic activity, thereby, it …
organelles. It belongs to the AAA+ family of proteases and has proteolytic activity, thereby, it …
[PDF][PDF] Funing Lin
Caseinolytic proteases (ClpPs) are complex serine proteases/endopeptidases regulated by
chaperone proteins of the AAA+ superfamily (ATPases Associated with diverse cellular …
chaperone proteins of the AAA+ superfamily (ATPases Associated with diverse cellular …
Methods and compositions for treating obesity and/or diabetes and for identifying candidate treatment agents
NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O= C ([C@ H](CO) NC
(= O)[C@ H](CC (C) C) NC (= O)[C@ H](CC (O)= O) NC (= O)[C@ H](CC (C) C) NC …
(= O)[C@ H](CC (C) C) NC (= O)[C@ H](CC (O)= O) NC (= O)[C@ H](CC (C) C) NC …