Hemophilia A and B are rare X‐linked inherited bleeding disorders caused by complete or
partial deficiency in or the absence of coagulation factors VIII and IX. Recurrent joint …

Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation
and lipid peroxidation. It is closely related to multiple biological processes, including iron …

The vascular endothelium has several important functions, including hemostasis. The
homeostasis of hemostasis is based on a fine balance between procoagulant and …

Haemarthroses cause major morbidity in patients with haemophilia. Blood has devastating
effects on all joint components, resulting in synovitis, osteochondral degeneration and …

Hemophilia is a congenital clotting factor deficiency characterized by spontaneous and
trauma-related bleeding. Spontaneous bleeding shows a predilection for joints, and …

Hemophilic arthropathy is a form of joint disease that develops secondary to joint bleeding
and presents with synovial hypertrophy, cartilage and bony destruction. The arthropathy can …

Factor VIII protein (FVIII) as a coagulation replacement factor has for decades been used as
the standard of care for management of people with haemophilia A. It is effective for …

Joint bleeds cause major morbidity in haemophilia patients. The synovial tissue is
responsible for removal of blood remnants from the joint cavity. But blood components …

Haemophilic arthropathy (HA), caused by intra-articular haemorrhage, is one of the most
common complications in patients with haemophilia. Factor replacement therapy provides …

Introduction For persons with hemophilia, optimization of joint outcomes is an important
unmet need. The aim of this initiative was to determine use of ultrasound in evaluating …