Smoking changes adaptive immunity with persistent effects

V Saint-André, B Charbit, A Biton, V Rouilly… - Nature, 2024 - nature.com
Individuals differ widely in their immune responses, with age, sex and genetic factors having
major roles in this inherent variability,,,,–. However, the variables that drive such differences …

[HTML][HTML] Mathematical modeling of regulatory networks of intracellular processes–Aims and selected methods

M Kardynska, D Kogut, M Pacholczyk… - Computational and …, 2023 - Elsevier
Regulatory networks structure and signaling pathways dynamics are uncovered in time-and
resource consuming experimental work. However, it is increasingly supported by modeling …

From Data to Cure: A Comprehensive Exploration of Multi-omics Data Analysis for Targeted Therapies

A Mukherjee, S Abraham, A Singh, S Balaji… - Molecular …, 2024 - Springer
In the dynamic landscape of targeted therapeutics, drug discovery has pivoted towards
understanding underlying disease mechanisms, placing a strong emphasis on molecular …

[HTML][HTML] E2F2 promotes lung adenocarcinoma progression through B-Myb-and FOXM1-facilitated core transcription regulatory circuitry

K Du, S Sun, T Jiang, T Liu, X Zuo, X Xia… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Lung adenocarcinoma (LUAD) causes severe cancer death worldwide. E2F2 is a canonical
transcription factor implicated in transcription regulation, cell cycle and tumorigenesis. The …

Growth-regulating factor 15-mediated gene regulatory network enhances salt tolerance in poplar

W Xu, Y Wang, J Xie, S Tan, H Wang, Y Zhao… - Plant …, 2023 - academic.oup.com
Soil salinity is an important determinant of crop productivity and triggers salt stress response
pathways in plants. The salt stress response is controlled by transcriptional regulatory …

Approaches for benchmarking single-cell gene regulatory network inference methods

Y Uzun - arXiv preprint arXiv:2307.08463, 2023 - arxiv.org
Gene regulatory networks are powerful tools for modeling interactions among genes to
regulate their expression for homeostasis and differentiation. Single-cell sequencing offers a …

Characteristics of NAC transcription factors in Solanaceae crops and their roles in responding to abiotic and biotic stresses

X Ou, L Sun, Y Chen, Z Zhao, W Jian - Biochemical and Biophysical …, 2024 - Elsevier
As one of the largest transcription factor (TF) families in plants, the NAC (NAM, ATAF1/2, and
CUC2) family plays important roles in response pathways to various abiotic and biotic …

Advances in computational and experimental approaches for deciphering transcriptional regulatory networks: Understanding the roles of cis‐regulatory elements is …

C Moeckel, I Mouratidis, N Chantzi, Y Uzun… - …, 2024 - Wiley Online Library
Understanding the influence of cis‐regulatory elements on gene regulation poses numerous
challenges given complexities stemming from variations in transcription factor (TF) binding …

Mr. Vc v2: An updated version of database with increased data of transcriptome and experimental validated interactions

Z Zhang, G Chen, W Hussain, Z Qin, J Liu… - Frontiers in …, 2022 - frontiersin.org
Mr. Vc is a database of curated Vibrio cholerae transcriptome data and annotated
information. The main objective is to facilitate the accessibility and reusability of the rapidly …

Molecular Regulatory Mechanisms Drive Emergent Pathogenetic Properties of Neisseria gonorrhoeae

A Sunkavalli, R McClure, C Genco - Microorganisms, 2022 - mdpi.com
Neisseria gonorrhoeae is the causative agent of the sexually transmitted infection (STI)
gonorrhea, with an estimated 87 million annual cases worldwide. N. gonorrhoeae …