Ageing can be defined as the progressive failure of repair and maintenance systems with a
consequent accumulation of cellular damage in nucleic acids, proteins, and lipids. These …

Proteoglycosylation is the addition of monosaccharides or glycans to the protein peptide
chain. This is a common post-translational modification of proteins with a variety of biological …

Diabetes is constantly increasing at a rate that outpaces genetic variation and approaches to
pandemic magnitude. Skin cells physiology and the cutaneous healing response are …

Senescence of renal tubular epithelial cells plays an important role in diabetic nephropathy,
but the mechanism is unknown. Metformin may alleviate diabetic nephropathy by reducing …

Modern understanding of aging is based on the accumulation of cellular damage during
one's life span due to the gradual deterioration of regenerative mechanisms in response to …

The protective effects and mechanisms of metformin against oxidative stress were evaluated
both in vivo and in vitro. ARPE‐19 cells comprised the normal group, the glyoxal‐treated …

Current evidence strongly suggests that aberrant activation of the nuclear factor kappa B (NF-
kB) signaling cascade is connected to carcinogenesis. The matrix metalloproteinases (MMP) …

Background This study aimed to investigate the effects of metformin on gingival wound
healing in insulin‐resistant prediabetes. Methods C57BL/6J mice were fed normal diet (ND) …

Identifying effective anti-aging compounds is a cornerstone of modern longevity, aging, and
skin-health research. There is considerable evidence of the effectiveness of nutrient …

Metformin has been successfully used as an anti-aging agent but exact molecular
mechanisms of metformin in anti-aging remain unknown. Hyperglycemia during skin aging …