Abstract Type 2 diabetes (T2DM) results when increases in beta cell function and/or mass
cannot compensate for rising insulin resistance. Numerous studies have documented the …

In β cells, stimulation by metabolic, hormonal, neuronal, and pharmacological factors is
coupled to secretion of insulin through different intracellular signaling pathways. Our …

Key points We used a mouse expressing a light‐sensitive ion channel in β‐cells to
understand how α‐cell activity is regulated by β‐cells. Light activation of β‐cells triggered a …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

The pancreatic β-cell secretes insulin in response to elevated plasma glucose. This review
applies an external bioenergetic critique to the central processes of glucose-stimulated …

Pancreatic islets are highly interconnected structures that produce pulses of insulin and
other hormones, maintaining normal homeostasis of glucose and other nutrients. Normal …

Functional pancreatic islet beta cells are essential to ensure glucose homeostasis across
species from zebrafish to humans. These cells show significant heterogeneity, and emerging …

Bursting is one of the fundamental rhythms that excitable cells can generate either in
response to incoming stimuli or intrinsically. It has been a topic of intense research in …

The construction of a predictive model of an entire eukaryotic cell that describes its dynamic
structure from atomic to cellular scales is a grand challenge at the intersection of biology …

Pancreatic islets are mini-organs composed of hundreds or thousands of ɑ, β and δ-cells,
which, respectively, secrete glucagon, insulin and somatostatin, key hormones for the …