MicroRNA biomarkers in IBD—differential diagnosis and prediction of colitis-associated cancer

JP James, LB Riis, M Malham, E Høgdall… - International journal of …, 2020 - mdpi.com
Inflammatory bowel disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC).
These are chronic autoimmune diseases of unknown etiology affecting the gastrointestinal …

miRNAs as therapeutic targets in inflammatory disease

Q Lu, R Wu, M Zhao, A Garcia-Gomez… - Trends in pharmacological …, 2019 - cell.com
In the past decade, we have witnessed considerable developments in understanding the
roles and functions of miRNAs. In parallel, the identification of alterations in miRNA …

Suppression of microRNA-222-3p ameliorates ulcerative colitis and colitis-associated colorectal cancer to protect against oxidative stress via targeting BRG1 to …

X Wang, D Zhang, Y Yang, X Li, H Li, X Zhang… - Frontiers in …, 2023 - frontiersin.org
Oxidative stress is an important pathogenic factor in ulcerative colitis (UC) and colitis-
associated colorectal cancer (CAC), further impairing the entire colon. Intestinal epithelial …

A panel of methylated microRNA biomarkers for identifying high-risk patients with ulcerative colitis-associated colorectal cancer

Y Toiyama, Y Okugawa, K Tanaka, T Araki, K Uchida… - Gastroenterology, 2017 - Elsevier
Background & Aims Methylation of specific microRNAs (miRNAs) often occurs in an age-
dependent manner, as a field defect in some instances, and may be an early event in colitis …

Circulating microRNA146b‐5p is superior to C‐reactive protein as a novel biomarker for monitoring inflammatory bowel disease

P Chen, Y Li, L Li, Q Yu, K Chao, G Zhou… - Alimentary …, 2019 - Wiley Online Library
Background Owing to the importance of early treatment, simple and reliable methods for
monitoring inflammatory bowel disease (IBD) are needed. Aims To determine whether …

miR‑146b‑5p promotes colorectal cancer progression by targeting TRAF6

L Shi, Y Su, Z Zheng, J Qi… - Experimental and …, 2022 - spandidos-publications.com
Increasing evidence highlights the multiple roles of microRNAs (miRs) in the tumorigenesis
of colorectal cancer (CRC); however, the molecular mechanism, particularly the target of …

Fatty acid amide hydrolase (FAAH) blockade ameliorates experimental colitis by altering microRNA expression and suppressing inflammation

H Shamran, NP Singh, EE Zumbrun, A Murphy… - Brain, behavior, and …, 2017 - Elsevier
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), which is thought to result from immune-mediated inflammatory disorders, leads to high …

[HTML][HTML] LncRNA LINC00313 knockdown inhibits tumorigenesis and metastasis in human osteosarcoma by upregulating FOSL2 through sponging miR-342-3p

H Chen, P Wahafu, L Wang, X Chen - Yonsei medical journal, 2020 - ncbi.nlm.nih.gov
Purpose Osteosarcoma (OS) is the most common primary bone tumor, with high morbidity in
infants and adolescents. Long noncoding RNA LINC00313 has been found to modulate …

The role of microRNAs upon epithelial-to-mesenchymal transition in inflammatory bowel disease

É Boros, I Nagy - Cells, 2019 - mdpi.com
Increasing evidence suggest the significance of inflammation in the progression of cancer,
for example the development of colorectal cancer in Inflammatory Bowel Disease (IBD) …

Increased expression of microRNA-141-3p improves necrotizing enterocolitis of neonates through targeting MNX1

H Chen, L Zeng, W Zheng, X Li, B Lin - Frontiers in Pediatrics, 2020 - frontiersin.org
Objective: MicroRNA-141-3p (miR-141-3p) has been investigated in various kinds of
cancers. This research delves into the functions and regulatory mechanisms of miR-141-3p …