Research progress in predicting DNA methylation modifications and the relation with human diseases

C Ao, L Gao, L Yu - Current Medicinal Chemistry, 2022 - ingentaconnect.com
DNA methylation is an important mode of regulation in epigenetic mechanisms, and it is one
of the research foci in the field of epigenetics. DNA methylation modification affects a series …

Deep transformers and convolutional neural network in identifying DNA N6-methyladenine sites in cross-species genomes

NQK Le, QT Ho - Methods, 2022 - Elsevier
As one of the most common post-transcriptional epigenetic modifications, N6-methyladenine
(6 mA), plays an essential role in various cellular processes and disease pathogenesis …

SDM6A: a web-based integrative machine-learning framework for predicting 6mA sites in the rice genome

S Basith, B Manavalan, TH Shin, G Lee - Molecular Therapy-Nucleic Acids, 2019 - cell.com
DNA N 6-adenine methylation (6mA) is an epigenetic modification in prokaryotes and
eukaryotes. Identifying 6mA sites in rice genome is important in rice epigenetics and …

Impacts of pseudo amino acid components and 5-steps rule to proteomics and proteome analysis

KC Chou - Current topics in medicinal chemistry, 2019 - ingentaconnect.com
Stimulated by the 5-steps rule during the last decade or so, computational proteomics has
achieved remarkable progresses in the following three areas:(1) protein structural class …

Classifying promoters by interpreting the hidden information of DNA sequences via deep learning and combination of continuous fasttext N-grams

NQK Le, EKY Yapp, N Nagasundaram… - … in bioengineering and …, 2019 - frontiersin.org
A promoter is a short region of DNA (100–1,000 bp) where transcription of a gene by RNA
polymerase begins. It is typically located directly upstream or at the 5′ end of the …

A convolutional neural network using dinucleotide one-hot encoder for identifying DNA N6-methyladenine sites in the rice genome

Z Lv, H Ding, L Wang, Q Zou - Neurocomputing, 2021 - Elsevier
Abstract N6-methyladenine (m 6 A) is one of the crucial epigenetic modifications and is
related to the control of various DNA processes. Carrying out a genome-wide m 6 A analysis …

Using deep neural networks and biological subwords to detect protein S-sulfenylation sites

DT Do, TQT Le, NQK Le - Briefings in Bioinformatics, 2021 - academic.oup.com
Protein S-sulfenylation is one kind of crucial post-translational modifications (PTMs) in which
the hydroxyl group covalently binds to the thiol of cysteine. Some recent studies have shown …

A computational framework based on ensemble deep neural networks for essential genes identification

NQK Le, DT Do, TNK Hung, LHT Lam… - International journal of …, 2020 - mdpi.com
Essential genes contain key information of genomes that could be the key to a
comprehensive understanding of life and evolution. Because of their importance, studies of …

XG-PseU: an eXtreme Gradient Boosting based method for identifying pseudouridine sites

K Liu, W Chen, H Lin - Molecular Genetics and Genomics, 2020 - Springer
As one of the most popular post-transcriptional modifications, pseudouridine (Ψ) participates
in a series of biological processes. Therefore, the efficient detection of pseudouridine sites is …

[HTML][HTML] Using extreme gradient boosting to identify origin of replication in Saccharomyces cerevisiae via hybrid features

DT Do, NQK Le - Genomics, 2020 - Elsevier
DNA replication is a fundamental task that plays a crucial role in the propagation of all living
things on earth. Hence, the accurate identification of its origin could be the key to giving an …