Cancer is driven by multiple types of genetic alterations, which range in size from point
mutations to whole-chromosome gains and losses, known as aneuploidy. Chromosome …

Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

Mammalian embryos sequentially differentiate into trophectoderm and an inner cell mass,
the latter of which differentiates into primitive endoderm and epiblast. Trophoblast stem (TS) …

Abnormal increases in cell size are associated with senescence and cell cycle exit. The
mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain …

Less than half of human zygotes survive to birth, primarily due to aneuploidies of meiotic or
mitotic origin. Mitotic errors generate chromosomal mosaicism, defined by multiple cell …

In eukaryotes, the cell volume is observed to be strongly correlated with the nuclear volume.
The slope of this correlation depends on the cell type, growth condition, and the physical …

Invasive fungal infections are a leading global cause of human mortality. Only three major
classes of antifungal drugs are widely used, and resistance to all three classes can arise …

Fungal species have dynamic genomes and often exhibit genomic plasticity in response to
stress. This genome plasticity often comes with phenotypic consequences that affect fitness …

Copy number variants (CNVs), duplications and deletions of genomic sequences, contribute
to evolutionary adaptation but can also confer deleterious effects and cause disease …

Mechanisms of evolution and evolution of antibiotic resistance are both fundamental and
world health problems. Stress-induced mutagenesis defines mechanisms of mutagenesis …