Synthetic lethality is a lethal phenomenon in which the occurrence of a single genetic event
is tolerable for cell survival, whereas the co-occurrence of multiple genetic events results in …

In recent years, CRISPR–Cas9 technology is widely acknowledged for having major
applications in the field of biotechnology for editing genome of any organism to treat a …

Fungal pathogens represent a major human threat affecting more than a billion people
worldwide. Invasive infections are on the rise, which is of considerable concern because …

Biological functions are orchestrated by intricate networks of interacting genetic elements.
Predicting the interaction landscape remains a challenge for systems biology and new …

Saccharomyces cerevisiae is a versatile microbial platform to build synthetic metabolic
pathways for production of diverse chemicals. To expedite the construction of complex …

CRISPR-Cas9 functional genomic screens uncover gene targets linked to various
phenotypes for metabolic engineering with remarkable efficiency. However, these genome …

Genome editing technology has progressed rapidly in recent years. Although traditional
gene-editing methods, including homologous recombination, zinc finger endonucleases …

The Candida genus encompasses a diverse group of ascomycete fungi that have captured
the attention of the scientific community, due to both their role in pathogenesis and emerging …

The probiotic yeast Saccharomyces boulardii (Sb) is a promising chassis to deliver
therapeutic proteins to the gut due to Sb's innate therapeutic properties, resistance to phage …

All living cells are coated with a diverse collection of carbohydrate molecules called glycans.
Glycans are key regulators of cell behavior and important therapeutic targets for human …