Population genomics of Klebsiella pneumoniae

KL Wyres, MMC Lam, KE Holt - Nature Reviews Microbiology, 2020 - nature.com
Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

Hypervirulent Klebsiella pneumoniae – clinical and molecular perspectives

JE Choby, J Howard‐Anderson… - Journal of internal …, 2020 - Wiley Online Library
Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a concerning global
pathogen. hvKp is more virulent than classical K. pneumoniae (cKp) and capable of causing …

Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae

RM Martin, MA Bachman - Frontiers in cellular and infection …, 2018 - frontiersin.org
Klebsiella pneumoniae is a Gram-negative pathogen that has a large accessory genome of
plasmids and chromosomal gene loci. This accessory genome divides K. pneumoniae …

Virulence Factors in Hypervirulent Klebsiella pneumoniae

J Zhu, T Wang, L Chen, H Du - Frontiers in microbiology, 2021 - frontiersin.org
Hypervirulent Klebsiella pneumoniae (hvKP) has spread globally since first described in the
Asian Pacific Rim. It is an invasive variant that differs from the classical K. pneumoniae …

Functional and genomic variation between human-derived isolates of Lachnospiraceae reveals inter-and intra-species diversity

MT Sorbara, ER Littmann, E Fontana, TU Moody… - Cell host & …, 2020 - cell.com
Bacteria belonging to the Lachnospiraceae family are abundant, obligate anaerobic
members of the microbiota in healthy humans. Lachnospiraceae impact their hosts by …

Klebsiella pneumoniae: going on the offense with a strong defense

MK Paczosa, J Mecsas - Microbiology and molecular biology …, 2016 - Am Soc Microbiol
Klebsiella pneumoniae causes a wide range of infections, including pneumonias, urinary
tract infections, bacteremias, and liver abscesses. Historically, K. pneumoniae has caused …

Carbapenem resistance-encoding and virulence-encoding conjugative plasmids in Klebsiella pneumoniae

X Yang, N Dong, EWC Chan, R Zhang, S Chen - Trends in microbiology, 2021 - cell.com
Klebsiella pneumoniae has an exceptional ability to acquire exogenous resistance-
encoding and hypervirulence-encoding genetic elements. In this review we trace the key …

Current status and development prospects of aquatic vaccines

Y Du, X Hu, L Miao, J Chen - Frontiers in immunology, 2022 - frontiersin.org
Diseases are a significant impediment to aquaculture's sustainable and healthy growth. The
aquaculture industry is suffering significant financial losses as a result of the worsening …

Genetic diversity, mobilisation and spread of the yersiniabactin-encoding mobile element ICEKp in Klebsiella pneumoniae populations

MMC Lam, RR Wick, KL Wyres… - Microbial …, 2018 - microbiologyresearch.org
Mobile genetic elements (MGEs) that frequently transfer within and between bacterial
species play a critical role in bacterial evolution, and often carry key accessory genes that …

[HTML][HTML] The staphylococcal exopolysaccharide PIA–Biosynthesis and role in biofilm formation, colonization, and infection

HTT Nguyen, TH Nguyen, M Otto - Computational and Structural …, 2020 - Elsevier
Exopolysaccharide is a key part of the extracellular matrix that contributes to important
mechanisms of bacterial pathogenicity, most notably biofilm formation and immune evasion …