Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC)

S Mohandas, P Jagannathan, TJ Henrich, ZA Sherif… - Elife, 2023 - elifesciences.org
With a global tally of more than 500 million cases of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections to date, there are growing concerns about the post …

Biological roles of fibroblasts in periodontal diseases

K Naruishi - Cells, 2022 - mdpi.com
Periodontal diseases include periodontitis and gingival overgrowth. Periodontitis is a
bacterial infectious disease, and its pathological cascade is regulated by many inflammatory …

T-helper cells and their cytokines in pathogenesis and treatment of asthma

T Ji, H Li - Frontiers in Immunology, 2023 - frontiersin.org
Prosperous advances in understanding the cellular and molecular mechanisms of chronic
inflammation and airway remodeling in asthma have been made over the past several …

Inflammation and the potential implication of macrophage-microglia polarization in human ASD: an overview

N Lampiasi, R Bonaventura, I Deidda, F Zito… - International Journal of …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a heterogeneous collection of neurodevelopmental
disorders, difficult to diagnose and currently lacking treatment options. The possibility of …

PD-1/LAG-3 bispecific antibody potentiates T cell activation and increases antitumor efficacy

N Shi, Y Zhou, Y Liu, R Zhang, X Jiang, C Ren… - Frontiers in …, 2022 - frontiersin.org
Several clinical studies demonstrate that there exist other immune checkpoints
overexpressed in some PD-1 inhibitor-resistant tumor patients. Among them, Lymphocyte …

Anti-inflammatory effects of serotonin receptor and transient receptor potential channel ligands in human small intestinal epithelial cells

GI Robinson, D Li, B Wang, Y Zahoruiko… - Current Issues in …, 2023 - mdpi.com
Intestinal inflammation and dysbiosis can lead to inflammatory bowel diseases (IBD) and
systemic inflammation, affecting multiple organs. Developing novel anti-inflammatory …

Therapeutic implications of current Janus kinase inhibitors as anti-COVID agents: A review

NK Jain, M Tailang, HK Jain… - Frontiers in …, 2023 - frontiersin.org
Severe cases of COVID-19 are characterized by hyperinflammation induced by cytokine
storm, ARDS leading to multiorgan failure and death. JAK-STAT signaling has been …

SARS-CoV-2 as an oncolytic virus following reactivation of the immune system: a review

JP Bounassar-Filho, L Boeckler-Troncoso… - International Journal of …, 2023 - mdpi.com
The effects SARS-CoV-2 inflicts on human physiology, especially in patients who developed
COVID-19, can range from flu-like symptoms to death, and although many lives have been …

The effect of sodium-glucose co-transporter-2 (SGLT2) inhibitors on blood interleukin-6 concentration: a systematic review and meta-analysis of randomized controlled …

S Gohari, F Ismail-Beigi, M Mahjani, S Ghobadi… - BMC Endocrine …, 2023 - Springer
Background The low-grade chronic inflammation in diabetes plays an important role in
development of cardiovascular and renal complications. Sodium-glucose co-transporter-2 …

Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease

M Bettinetti‐Luque, L Trujillo‐Estrada… - British Journal of …, 2024 - Wiley Online Library
Adipose tissue has recently been recognized as an important endocrine organ that plays a
crucial role in energy metabolism and in the immune response in many metabolic tissues …