The claustrum

JB Smith, AK Lee, J Jackson - Current Biology, 2020 - cell.com
The claustrum is a brain region that has been investigated for over 200 years, yet its precise
function remains unknown. In the final posthumously released article of Francis Crick, written …

A review of functional and structural neuroimaging studies to investigate the inner speech model of auditory verbal hallucinations in schizophrenia

L Barber, R Reniers, R Upthegrove - Translational psychiatry, 2021 - nature.com
Although the pathophysiology of auditory verbal hallucinations remains uncertain, the inner
speech model remains a prominent theory. A systematic review and meta-analyses of both …

Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses

M Niu, A Kasai, M Tanuma, K Seiriki, H Igarashi… - Science …, 2022 - science.org
The processing of stress responses involves brain-wide communication among cortical and
subcortical regions; however, the underlying mechanisms remain elusive. Here, we show …

Optogenetic stimulation of anterior insular cortex neurons in male rats reveals causal mechanisms underlying suppression of the default mode network by the salience …

V Menon, D Cerri, B Lee, R Yuan, SH Lee… - Nature …, 2023 - nature.com
The salience network (SN) and default mode network (DMN) play a crucial role in cognitive
function. The SN, anchored in the anterior insular cortex (AI), has been hypothesized to …

Neural activity in the mouse claustrum in a cross-modal sensory selection task

M Chevée, EA Finkel, SJ Kim, DH O'Connor, SP Brown - Neuron, 2022 - cell.com
The claustrum, a subcortical nucleus forming extensive connections with the neocortex, has
been implicated in sensory selection. Sensory-evoked claustrum activity is thought to …

The anatomy and physiology of claustrum-cortex interactions

J Jackson, JB Smith, AK Lee - Annual review of neuroscience, 2020 - annualreviews.org
The claustrum is one of the most widely connected regions of the forebrain, yet its function
has remained obscure, largely due to the experimentally challenging nature of targeting this …

Psychedelic therapy's transdiagnostic effects: a research domain criteria (RDoC) perspective

JR Kelly, CM Gillan, J Prenderville, C Kelly… - Frontiers in …, 2021 - frontiersin.org
Accumulating clinical evidence shows that psychedelic therapy, by synergistically combining
psychopharmacology and psychological support, offers a promising transdiagnostic …

Pain-induced adaptations in the claustro-cingulate pathway

NR Ntamati, MA Acuña, T Nevian - Cell reports, 2023 - cell.com
Persistent pain is a prevalent medical concern correlating with a hyperexcitable anterior
cingulate cortex (ACC). Its activity is modulated by inputs from several brain regions, but the …

Human lesions and animal studies link the claustrum to perception, salience, sleep and pain

H Atilgan, M Doody, DK Oliver, TM McGrath… - Brain, 2022 - academic.oup.com
The claustrum is the most densely interconnected region in the human brain. Despite the
accumulating data from clinical and experimental studies, the functional role of the claustrum …

Influence of claustrum on cortex varies by area, layer, and cell type

EG McBride, SR Gandhi, JR Kuyat, DR Ollerenshaw… - Neuron, 2023 - cell.com
The claustrum is a small subcortical structure with widespread connections to disparate
regions of the cortex. However, the impact of the claustrum on cortical activity is not fully …