The Piezo channel family, including Piezo1 and Piezo2, includes essential
mechanosensitive transduction molecules in mammals. Functioning in the conversion of …

Cardiac fibroblasts (CF) play a pivotal role in preserving myocardial function and integrity of
the heart tissue after injury, but also contribute to future susceptibility to heart failure. CF …

T lymphocytes encounter complex mechanical cues during an immune response. The
mechanosensitive ion channel, Piezo1, drives inflammatory responses to bacterial …

Glucose-induced insulin secretion depends on β-cell electrical activity. Inhibition of ATP-
regulated potassium (KATP) channels is a key event in this process. However, KATP …

Piezo1 channels are essential mechanically activated ion channels in vertebrates. Their
selective activation by the synthetic chemical activator Yoda1 opened new avenues to probe …

Abstract Purpose of Review: Atherosclerosis is the principal cause of cardiovascular
diseases (CVDs) which are the major cause of death worldwide. Mechanical force plays an …

All cells in the body are exposed to physical force in the form of tension, compression,
gravity, shear stress, or pressure. Cells convert these mechanical cues into intracellular …

Pancreatic β-cells have been reported to be mechanosensitive to cellular
microenvironments, and subjecting the cells to more physiologically relevant …

Acute pancreatitis (AP) is a common inflammatory disease of the digestive system.
Mitochondrial calcium uniporter (MCU) mediates mitochondrial uptake of Ca 2+ and plays …

Piezo1, a non-selective cation channel directly activated by mechanical forces, is widely
expressed in the digestive system and participates in biological functions physiologically …