The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential

GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - Elsevier
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

[HTML][HTML] Smooth muscle ion channels and regulation of vascular tone in resistance arteries and arterioles

NR Tykocki, EM Boerman… - Comprehensive Physiology, 2017 - ncbi.nlm.nih.gov
Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Discovery and development of calcium channel blockers

T Godfraind - Frontiers in pharmacology, 2017 - frontiersin.org
In the mid 1960s, experimental work on molecules under screening as coronary dilators
allowed the discovery of the mechanism of calcium entry blockade by drugs later named …

Signaling mechanisms underlying the vascular myogenic response

MJ Davis, MA Hill - Physiological reviews, 1999 - journals.physiology.org
The vascular myogenic response refers to the acute reaction of a blood vessel to a change
in transmural pressure. This response is critically important for the development of resting …

[HTML][HTML] Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders

S Heyes, WS Pratt, E Rees, S Dahimene, L Ferron… - Progress in …, 2015 - Elsevier
This review summarises genetic studies in which calcium channel genes have been
connected to the spectrum of neuropsychiatric syndromes, from bipolar disorder and …

Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells

TF McDonald, S Pelzer, W Trautwein… - Physiological …, 1994 - journals.physiology.org
I. OVERVIEW AND NOMENCLATURE Times change. In 1926, the writer of a review in this
journal noted that over 350 papers had appeared on the subject during the previous 2 years …

Evolving mechanisms of vascular smooth muscle contraction highlight key targets in vascular disease

Z Liu, RA Khalil - Biochemical pharmacology, 2018 - Elsevier
Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function.
Identifying the mechanisms of VSM contraction has been a major research goal in order to …

Increase in single L-type calcium channels in hippocampal neurons during aging

O Thibault, PW Landfield - Science, 1996 - science.org
Voltage-activated calcium (Ca2+) influx is increased in mammalian CA1 hippocampal
neurons during aging. However, the molecular basis for this elevation is not known. The …

Cloning and Characterization of α1H From Human Heart, a Member of the T-Type Ca2+ Channel Gene Family

LL Cribbs, JH Lee, J Yang, J Satin, Y Zhang… - Circulation …, 1998 - Am Heart Assoc
Voltage-activated Ca2+ channels exist as multigene families that share common structural
features. Different Ca2+ channels are distinguished by their electrophysiology and …

The mechanism of action of peppermint oil on gastrointestinal smooth muscle: an analysis using patch clamp electrophysiology and isolated tissue pharmacology in …

JM Hills, PI Aaronson - Gastroenterology, 1991 - Elsevier
An investigation of the mechanism of peppermint oil action was performed using isolated
pharmacological preparations from guinea pig large intestine and patch clamp …