Glucose-responsive microneedle patch for closed-loop dual-hormone delivery in mice and pigs

C Yang, T Sheng, W Hou, J Zhang, L Cheng… - Science …, 2022 - science.org
Insulin and glucagon secreted from the pancreas with dynamic balance play a vital role in
regulating blood glucose levels. Although distinct glucose-responsive insulin delivery …

Dilemma on plasmid DNA purification: Binding capacity vs selectivity

JFA Valente, JA Queiroz, F Sousa - Journal of Chromatography A, 2021 - Elsevier
Plasmid DNA chromatography is a powerful field in constant development and evolution.
The use of this technique is considered mandatory in the production of an efficient and safe …

Production and purification of plasmid DNA vaccines: is there scope for further innovation?

A Xenopoulos, P Pattnaik - Expert review of vaccines, 2014 - Taylor & Francis
The demand for plasmid DNA (pDNA) has vastly increased over the past decade in
response to significant advances that have been made in its application for gene therapy …

Spatiotemporal immunomodulation and biphasic osteo‐vascular aligned electrospun membrane for diabetic periosteum regeneration

Y Qiao, L Yu, P Yang, M Chen, H Sun… - Advanced …, 2023 - Wiley Online Library
Under diabetic conditions, blood glucose fluctuations and exacerbated immunopathological
inflammatory environments pose significant challenges to periosteal regenerative repair …

Applications of reversible covalent chemistry in analytical sample preparation

D Siegel - Analyst, 2012 - pubs.rsc.org
Reversible covalent chemistry (RCC) adds another dimension to commonly used sample
preparation techniques like solid-phase extraction (SPE), solid-phase microextraction …

Negative chromatography: Progress, applications and future perspectives

MFX Lee, ES Chan, BT Tey - Process Biochemistry, 2014 - Elsevier
In negative chromatography, the impurities bind on the adsorbent, and the product is
allowed to flow through the chromatographic column. Negative chromatography is an …

Fluorophenylboronic acid substituted chitosan for insulin loading and release

L Luo, R Song, J Chen, B Zhou, X Mao… - Reactive and Functional …, 2020 - Elsevier
Phenylboronic acid (PBA) can form dynamical reversible chemical bonds with sugars, and
has potential in glucose response and controlling insulin delivery. In this paper, 4 …

Phenylboronic acid as a multi-modal ligand for the capture of monoclonal antibodies: development and optimization of a washing step

R dos Santos, SASL Rosa, MR Aires-Barros… - … of Chromatography A, 2014 - Elsevier
In this work, phenylboronic acid (PBA) was thoroughly investigated as a synthetic ligand for
the purification of an immunoglobulin G (IgG) from a clarified cell supernatant from Chinese …

Boronic acid-modified magnetic materials for antibody purification

VL Dhadge, A Hussain… - Journal of The …, 2014 - royalsocietypublishing.org
Aminophenyl boronic acids can form reversible covalent ester interactions with cis-diol-
containing molecules, serving as a selective tool for binding glycoproteins as antibody …

Development of boronic acid-functionalized mesoporous silica-coated core/shell magnetic microspheres with large pores for endotoxin removal

Y Ji, W Li, W Fu, J Pang, P Zhao - Journal of Chromatography A, 2019 - Elsevier
Endotoxins are found almost everywhere and possess high toxicity in vivo and in vitro. Here
we design a novel boronate affinity material, called boronic acid-functionalized mesoporous …