Early transcriptomic host response signatures in the serum of dengue patients provides insights into clinical pathogenesis and disease severity

A Yadav, U Shamim, V Ravi, P Devi, P Kumari… - Scientific Reports, 2023 - nature.com
Dengue virus (DENV), known to cause viral infection, belongs to the family Flaviviridae,
having four serotypes (DENV1-4) that spreads by the bite of the Aedes aegypti mosquito …

Genome-wide association studies of COVID-19 vaccine seroconversion and breakthrough outcomes in UK Biobank

M Alcalde-Herraiz, M Català, A Prats-Uribe… - Nature …, 2024 - nature.com
Understanding the genetic basis of COVID-19 vaccine seroconversion is crucial to study the
role of genetics on vaccine effectiveness. In our study, we used UK Biobank data to find the …

SARS-CoV-2 infection severity and mortality is modulated by repeat-mediated regulation of alternative splicing

P Mehta, P Chattopadhyay, V Ravi, B Tarai… - Microbiology …, 2023 - Am Soc Microbiol
Like single-stranded RNA viruses, SARS-CoV-2 hijacks the host transcriptional machinery
for its own replication. Numerous traditional differential gene expression-based …

From bench to bedside: potential of translational research in COVID-19 and beyond

N Shukla, U Shamim, P Agarwal… - Briefings in …, 2024 - academic.oup.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus
disease 2019 (COVID-19) have been around for more than 3 years now. However, due to …

[HTML][HTML] Single-cell RNA-Seq reveals intracellular microbial diversity within immune cells during SARS-CoV-2 infection and recovery

S Yadav, P Mehta, J Soni, P Chattopadhyay, P Devi… - Iscience, 2023 - cell.com
Intracellular microorganisms, like viruses, bacteria, and fungi, pose challenges in detection
due to their non-culturable forms. Transcriptomic analysis at cellular level enables …

Intertwined dysregulation of ribosomal proteins and immune response delineates SARS-CoV-2 vaccination breakthroughs

R Maurya, U Shamim, P Mishra… - Microbiology …, 2023 - Am Soc Microbiol
Globally, COVID-19 vaccines have emerged as a boon, especially during the severe
pandemic phases to control the spread of severe acute respiratory syndrome coronavirus 2 …

Longitudinal transcriptional analysis of peripheral blood leukocytes in COVID-19 convalescent donors

MR Gedda, P Danaher, L Shao, M Ongkeko… - Journal of Translational …, 2022 - Springer
Background SARS-CoV2 can induce a strong host immune response. Many studies have
evaluated antibody response following SARS-CoV2 infections. This study investigated the …

In silico analyses identify sequence contamination thresholds for Nanopore-generated SARS-CoV-2 sequences

AJ Bolaji, AT Duggan - PLOS Computational Biology, 2024 - journals.plos.org
The SARS-CoV-2 pandemic has brought molecular biology and genomic sequencing into
the public consciousness and lexicon. With an emphasis on rapid turnaround, genomic data …

Immunopathogenesis of SARS-CoV-2 Variants in a Feline Model

MT Selvan - 2023 - search.proquest.com
SARS-CoV-2 is a rapidly spreading virus that causes immune disturbances leading to
cytokine storm and eventually organ failure. The advent of new technology, vaccines, and …

Immunopathogenesis of SARS-CoV-2 variants in a feline model

M Tamil Selvan - 2023 - openresearch.okstate.edu
SARS-CoV-2 is a rapidly spreading virus that causes immune disturbances leading to
cytokine storm and eventually organ failure. The advent of new technology, vaccines, and …