Ultrahigh dose-rate radiotherapy (RT), or'FLASH'therapy, has gained significant momentum
following various in vivo studies published since 2014 which have demonstrated a reduction …

The blood–brain barrier (BBB) is formed by brain microvascular endothelial cells that are
sealed by tight junctions, making it a significant obstacle for most brain therapeutics. The …

Ultra‐high‐dose rate “FLASH” radiotherapy (FLASH‐RT) has been shown to drastically
reduce normal tissue toxicities while being as efficacious as conventional dose rate …

Microbeam radiation therapy (MRT) uses highly collimated, quasi-parallel arrays of X-ray
microbeams of 50–600keV, produced by third generation synchrotron sources, such as the …

Dosimetry of ionising radiation is a well-established and mature branch of physical sciences
with many applications in medicine and biology. In particular radiotherapy relies on …

Abstract Stereotactic Synchrotron Radiotherapy (SSRT) and Microbeam Radiation Therapy
(MRT) are both novel approaches to treat brain tumor and potentially other tumors using …

A critical early phase for any synchrotron beamline involves detailed testing,
characterization and commissioning; this is especially true of a beamline as ambitious and …

Purpose: Modern radiotherapy modalities often use small or nonstandard fields to ensure
highly localized and precise dose delivery, challenging conventional clinical dosimetry …

To analyze the effects of the microbeam width (25, 50 and 75 µm) on the survival of 9L
gliosarcoma tumor-bearing rats and on toxicity in normal tissues in normal rats after …

This paper reviews the current state of the art of an emerging form of radiosurgery dedicated
to brain tumour treatment and which operates at very high dose rate (kGy· s− 1). Microbeam …