Through the success of basic and disease-specific research, cancer survivors are one of the
largest growing subsets of individuals accessing the healthcare system. Interestingly …

In the course of examining the effect of electric fields on the growth of Escherichia coli cells,
a biological activity of platinum compounds was uncovered that led to the development of …

Since the serendipitous discovery of the biological activity of cisplatin, 1 the drug has been
applied extensively in cancer chemotherapy. 2 Platinum-based drugs such as cisplatin …

Acute treatment with replication-stalling chemotherapeutics causes reversal of replication
forks. BRCA proteins protect reversed forks from nucleolytic degradation, and their loss …

Histone deacetylases (HDACs) play an important role in regulating target gene expression.
They have been highlighted as a novel category of anticancer targets, and their inhibition …

Anticancer drugs are a group of therapeutic agents used to enhance cell death in targeted
cell types of neoplasia. Because of frequent use and eventual discharge, they have been …

Publisher Summary Biomedical inorganic chemistry “Elemental Medicine” is an important
new area of chemistry. Platinum complexes are now among the most widely used drugs for …

Advances in analytical methodologies, principally nuclear magnetic resonance
spectroscopy (NMR) and mass spectrometry (MS), during the last decade have made large …

Two cobalt (III) Schiff base complexes, trans-[Co (salen)(DA) 2](ClO4)(1) and trans-[Co
(salophen)(DA) 2](ClO4)(2)(where salen: N, N'-bis (salicylidene) ethylenediamine, salopen …

Interstrand DNA crosslinks (ICLs) are formed by natural products of metabolism and by
chemotherapeutic reagents. Work in E. coli identified a two cycle repair scheme involving …