Acute liver failure (ALF) describes a clinical syndrome of rapid hepatocyte injury leading to
liver failure manifested by coagulopathy and encephalopathy in the absence of pre-existing …

Background Adenovirus is a known cause of hepatitis in immunocompromised children, but
not in immunocompetent children. In April, 2022, following multiple reports of hepatitis of …

Pediatric acute liver failure (PALF) is a rare, rapidly progressive clinical syndrome with
significant morbidity and mortality. The phenotype of PALF manifests as abrupt onset liver …

During October 2021–February 2022, a cluster of children with hepatitis of unknown etiology
and adenovirus infection was identified in the United States. On April 21, after reports of …

Results: In total, 260 indeterminate PALF patients from 19 countries were recruited between
2011 and 2022, of whom 59 had recurrent PALF. WES established a genetic diagnosis in …

Purpose This study aimed to define the genotypic and phenotypic spectrum of reversible
acute liver failure (ALF) of infancy resulting from biallelic pathogenic TRMU variants and …

Among genetic disorders of vesicular trafficking, there are three causing recurrent acute liver
failure (RALF): NBAS, RINT1, and SCYL1‐associated disease. These three disorders are …

Objectives: In many pediatric acute liver failure (PALF) cases, a diagnosis is not identified,
and the etiology is indeterminate (IND-PALF). Our pilot study found dense CD8 T-cell …

In 1989, a collaboration between the Centers for Disease Control (CDC) and a California
biotechnology company identified the hepatitis C virus (HCV, formerly known as non-A, non …

Purpose To develop a probability-based differential diagnosis for pediatric acute liver failure
(PALF) based on age and socioeconomic status of the country of origin. Methods …