Spin hyperpolarization in modern magnetic resonance

J Eills, D Budker, S Cavagnero, EY Chekmenev… - Chemical …, 2023 - ACS Publications
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

Parahydrogen‐based hyperpolarization for biomedicine

JB Hövener, AN Pravdivtsev, B Kidd… - Angewandte Chemie …, 2018 - Wiley Online Library
Magnetic resonance (MR) is one of the most versatile and useful physical effects used for
human imaging, chemical analysis, and the elucidation of molecular structures. However, its …

Instrumentation for hydrogenative parahydrogen-based hyperpolarization techniques

AB Schmidt, CR Bowers, K Buckenmaier… - Analytical …, 2022 - ACS Publications
The unique properties of the entangled, antisymmetric nuclear spin state of dihydrogen,
parahydrogen (pH2), has intrigued physicists, chemists, and other scientists for almost a …

Parahydrogen Hyperpolarization Allows Direct NMR Detection of α‐Amino Acids in Complex (Bio) mixtures

L Sellies, RLEG Aspers, MC Feiters… - Angewandte Chemie …, 2021 - Wiley Online Library
The scope of non‐hydrogenative parahydrogen hyperpolarization (nhPHIP) techniques has
been expanding over the last years, with the continuous addition of important classes of …

Heterogeneous Catalysis and Parahydrogen‐Induced Polarization

EV Pokochueva, DB Burueva, OG Salnikov… - …, 2021 - Wiley Online Library
Parahydrogen‐induced polarization with heterogeneous catalysts (HET‐PHIP) has been a
subject of extensive research in the last decade since its first observation in 2007. While …

Parahydrogen‐Induced Polarization of Amino Acids

AN Pravdivtsev, G Buntkowsky… - Angewandte Chemie …, 2021 - Wiley Online Library
Nuclear magnetic resonance (NMR) has become a universal method for biochemical and
biomedical studies, including metabolomics, proteomics, and magnetic resonance imaging …

Quasi-continuous production of highly hyperpolarized carbon-13 contrast agents every 15 seconds within an MRI system

AB Schmidt, M Zimmermann, S Berner… - Communications …, 2022 - nature.com
Hyperpolarized contrast agents (HyCAs) have enabled unprecedented magnetic resonance
imaging (MRI) of metabolism and pH in vivo. Producing HyCAs with currently available …

Design of nuclear magnetic resonance molecular probes for hyperpolarized bioimaging

Y Kondo, H Nonaka, Y Takakusagi… - Angewandte Chemie …, 2021 - Wiley Online Library
Nuclear hyperpolarization has emerged as a method to dramatically enhance the sensitivity
of NMR spectroscopy. By application of this powerful tool, small molecules with stable …

More Than 12 % Polarization and 20 Minute Lifetime of 15N in a Choline Derivative Utilizing Parahydrogen and a Rhodium Nanocatalyst in Water

J McCormick, S Korchak, S Mamone… - Angewandte …, 2018 - Wiley Online Library
Hyperpolarization techniques are key to extending the capabilities of MRI for the
investigation of structural, functional and metabolic processes in vivo. Recent …

Hyperpolarization of amino acids in water utilizing parahydrogen on a rhodium nanocatalyst

L Kaltschnee, AP Jagtap, J McCormick… - … A European Journal, 2019 - Wiley Online Library
NMR offers many possibilities in chemical analysis, structural investigations, and medical
diagnostics. Although it is broadly used, one of NMR spectroscopies main drawbacks is low …